Ultra-processed food consumption and risk of multiple chronic diseases among 8,819,894 adults from 51 prospective cohorts: a dose-response meta-analysis
Liu X, Luo S, Zeng Y, Peng N, Chen X, Tian J, Lin L, Zeng S, Xie Y, Wang Z, Xu J, Li L, Zhang D, Gu W, Gu X, Zhang J, Liu M, Zhao Y, Zhu L, Majeed MW, Yan Z, Wang W, Yu P
Family medicine and community health · 0 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Natural Science Foundation of Guangdong Province
- Gobierno
- Basic and Applied Basic Research Foundation of Guangdong Province
- Subvenciones
- National Natural Science Foundation of China (No.82100869); Basic and Applied Basic Research Foundation of Guangdong Province (202201011395); Natural Science Foundation of Guangdong Province (202201011395); National Natural Science Foundation of China (No.82360162); National Natural Science Foundation of China (82360162); National Natural Science Foundation of China (NO. 82160371)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2026-09-01 · Fam Med Community Health · vol. 14 · número Suppl 5 · pág. e003925
- Editorial
- BMJ
- Citado
- 0 citas
- Referencias
- 0 trabajos
- Acceso
- Acceso abierto (publicación gratuita) · CC-BY-NC
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Global Public Health Policies and Epidemiology
- Palabras clave
- ultra-processed foods, chronic disease risk, cardiovascular events, cancer, obesity, metabolic syndrome, diabetes mellitus, depression, anxiety, gastrointestinal diseases, all-cause mortality, dose-response relationship, dietary intake, adults, prospective cohort, dietary guidelines, nutrition policy, food regulation
- MeSH
- humans, cardiovascular diseases, chronic disease, risk factors, prospective studies, adult, female, male, fast foods
23 autores
- Xiao Liu🇨🇳🇸🇬Sun Yat-sen University; Sun Yat-sen Memorial Hospital; Duke-NUS Medical School
- Shengwei Luo🇸🇬🇨🇳National University of Singapore; Peking University
- Yunting Zeng🇨🇳Fujian University of Traditional Chinese Medicine
- Nanqin Peng🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
- Xinyi Chen🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
- Jianan Tian🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
- Ling Lin🇨🇳Fujian Medical University
- Shan Zeng🇨🇳First Affiliated Hospital of Gannan Medical University
- Yewei Xie🇸🇬SingHealth; National University of Singapore; SingHealth Duke-NUS Academic Medical Centre; Duke-NUS Medical School
- Zexuan Wang🇨🇳Heilongjiang University of Chinese Medicine
- Jiaxue Xu🇨🇳Sun Yat-sen University
- Li Lin🇨🇳Fujian University of Traditional Chinese Medicine
- Deju Zhang🇭🇰University of Hong Kong
- Wenli Gu🇨🇳🇭🇰Queen Mary Hospital; University of Hong Kong
- Xiang Gu🇨🇳Jiujiang University
- Jun Zhang🇨🇳Jiujiang University
- Menglu Liu
- Yujie Zhao
- Lihan Zhu🇰🇷Seoul National University
- Mir Wajid Majeed🇮🇳Safdarjang Hospital; Vardhman Mahavir Medical College & Safdarjung Hospital
- Zhiwei Yan🇨🇳Fujian Medical University
- Wenting Wang🇨🇳Hainan Medical University
- Peng Yu🇨🇳Nanchang University; Second Affiliated Hospital of Nanchang University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The consumption of ultra-processed foods (UPFs) has increased globally. This study comprehensively investigated the impact of consuming UPFs on the risk of major chronic diseases in adults.
Setting
A systematic search identified prospective cohort studies up to April 2026 on consumption of UPFs and major chronic outcomes. Consumption of UPFs was assessed by food frequency questionnaires (FFQs), 24-hour recalls, or dietary history.
Participants
Adults (≥18 years) without restriction to specific clinical conditions at baseline.
Results
Fifty-one prospective cohort studies involving 8 819 894 participants were included. Consumption of UPFs was associated with cardiovascular events (Hazard Ratio (HR) 1.24, 95% Confidence Interval (CI) 1.14 to 1.36), cancer (HR 1.12, 95% CI 1.04 to 1.21), obesity/overweight (HR 1.23, 95% CI 1.17 to 1.30), metabolic syndrome (MetS)/diabetes (HR 1.24, 95% CI 1.08 to 1.42), depression/anxiety (HR 1.27, 95% CI 1.15 to 1.40), digestive diseases (HR 1.31, 95% CI 1.16 to 1.48) and all-cause mortality (HR 1.18, 95% CI 1.10 to 1.26). Dose-response analyses showed each additional 100 g/day associated with higher risks of cardiovascular events (HR 1.14, 95% CI 1.06 to 1.22), cancer (HR 1.04, 95% CI 1.02 to 1.06), all-cause mortality (HR 1.03, 95% CI 1.02 to 1.05), and MetS/diabetes (HR 1.02, 95% CI 1.01 to 1.04).
Conclusions
Consuming UPFs was associated with higher risks of multiple chronic diseases and all-cause mortality with low or moderate evidence. Reducing dietary intake of UPFs may therefore be relevant for chronic disease prevention.
Prospero registration number
CRD42023421092.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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