Total ultra-processed food intake and selected food-group exposures in relation to non-alcoholic fatty liver disease: a systematic review and meta-analysis
Chen D, Li L, Zhang C
Frontiers in nutrition · 0 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-09-08 · Front Nutr · vol. 13 · pág. 1876449
- Editorial
- Frontiers Media
- Citado
- 0 citas · más que el 64% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Liver Disease Diagnosis and Treatment · Nutritional Studies and Diet
- Palabras clave
- ultra-processed foods, non-alcoholic fatty liver disease, NOVA classification, red meat, processed meat, sugar-sweetened beverages, dietary risk factors, cardiometabolic disease
3 autores
- Dongmei Chen🇨🇳Sichuan University; Chengdu Second People's Hospital
- Ling Li🇨🇳Sichuan University; Chengdu Second People's Hospital
- Chenglong Zhang🇨🇳 · autor de correspondenciaSichuan University; Chengdu Second People's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Ultra-processed food (UPF) consumption has been linked to cardiometabolic diseases, but the association with non-alcoholic fatty liver disease (NAFLD) remains unclear. Moreover, whether all UPFs confer similar risk is unknown.
Objective
To systematically review and meta-analyze the association between total UPF intake (strictly defined by NOVA classification) and selected UPF-related food-group exposures [red/processed meat and sugar-sweetened beverages (SSBs)] and NAFLD risk in adults.
Methods
We searched PubMed, Web of Science, and Cochrane Library up to March 31, 2026, for observational studies reporting adjusted effect estimates for total UPF intake or selected food-group exposures and NAFLD. Study quality was assessed using the Newcastle-Ottawa Scale (NOS) or AHRQ criteria. Random-effects models pooled odds ratios (ORs) comparing highest vs. lowest intake categories. Subgroup and sensitivity analyses explored heterogeneity.
Results
Twenty-four studies were included in the systematic review. Of these, nine studies (5 prospective cohorts, 4 cross-sectional) comprising 250,349 participants were included for total UPF intake. Higher total UPF consumption was associated with a 26% increased NAFLD risk (pooled OR = 1.26; 95% CI: 1.16-1.37; I2 = 53%; P 2 = 76%; P 2 = 0%; P < 0.001). Sensitivity analyses confirmed robustness.
Conclusion
Total UPF intake is associated with a moderate increase in NAFLD risk. Red/processed meat and sugar-sweetened beverages show stronger associations, suggesting that dietary recommendations may prioritize these high-risk food groups, although blanket avoidance of all UPFs is not directly supported by the current data.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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