Satiety responsiveness following dietary exposure to ultra-processed foods differing in texture-derived eating rate: a secondary analysis of a randomized controlled crossover diet intervention
van Bruinessen M, Liu Z, Heuven LAJ, Stieger M, Lasschuijt MP, Forde CG
European journal of nutrition · 0 citas
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- Posiblemente financiado por la industria
- Gobierno
- Topconsortium voor Kennis en Innovatie
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- Dutch Top-Consortium for Knowledge and Innovation Agri & Food (TKI-Agri-food)
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Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2026-09-24 · Eur J Nutr · vol. 65 · número 7
- Editorial
- Springer Science+Business Media
- Citado
- 0 citas · más que el 73% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Regulation of Appetite and Obesity · Consumer Attitudes and Food Labeling · Nutrition, Health and Food Behavior
- Palabras clave
- ultra-processed foods, satiety responsiveness, eating speed, texture, satiety hormones, glucagon-like peptide-1, ghrelin, pancreatic polypeptide, peptide YY, subjective appetite, hunger and fullness, mixed meal tolerance test, energy intake
- MeSH
- humans, peptide yy, pancreatic polypeptide, diet, cross-over studies, appetite, satiation, satiety response, energy intake, adult, female, male, glucagon-like peptide 1, ghrelin, young adult, fast foods
6 autores
- Marieke van Bruinessen🇳🇱Wageningen University & Research
- Zhen Liu🇳🇱Wageningen University & Research
- Lise A.J. Heuven🇳🇱Wageningen University & Research
- Markus Stieger🇳🇱Wageningen University & Research
- Marlou P. Lasschuijt🇳🇱Wageningen University & Research
- Ciaran Gerard Forde🇳🇱 · autor de correspondenciaWageningen University & Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Disrupted satiety signalling has been proposed as a possible mechanism driving high energy intakes associated with the consumption of ultra-processed foods (UPFs). We examined whether transitioning from a diet low in UPFs to a high-UPF diet affects satiety responsiveness.
Methods
In a randomized crossover trial, participants (n = 32; mean ± SD: age 27 ± 2 y; BMI 23.6 ± 2.3 kg/m2) with habitual low-UPF intakes completed two 14-day UPF diets (~ 95%EN from UPFs), separated by a 14-day washout period. Acute satiety responsiveness was assessed using a mixed-meal tolerance test with a fixed-calorie load at baseline and following each 14-day diet. Subjective appetite ratings and plasma concentrations of glucagon-like peptide-1 (GLP-1), ghrelin, pancreatic polypeptide (PP), and peptide YY (PYY) were measured from 10 min prior to 180 min following the fixed-calorie load. Satiety responsiveness was also assessed over-time within each UPF diet-arm, through daily fasting-state appetite ratings prior to breakfast.
Results
A small but significant difference was observed in acute subjective satiety ratings for total area under the curves (AUCs), with higher hunger and lower fullness AUCs following the high-UPF diets compared with baseline-measurements, though no significant differences were observed at individual timepoints (all, p > 0.05). Satiety hormone responses to the fixed-calorie load did not differ between baseline and following 14-day high-UPF exposure (all, p > 0.05). Within each diet period, fasting-state appetite ratings remained stable across days on both UPF diets.
Conclusion
Our results do not support the hypothesis that satiety responsiveness is disrupted following two 14-day periods of high-UPF diet exposure. The study was pre-registered at clinicaltrials.gov (NCT06113146).
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