Vitamin D receptor alleles and rates of bone loss: influences of years since menopause and calcium intake
Krall EA, Parry P, Lichter JB, Dawson-Hughes B
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 142 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- USDA Human Nutrition Research Center
Según 1 financiador declarado.
Publicación
- Publicado
- 1995-06-01 · J Bone Miner Res · vol. 10 · número 6 · págs. 978–984
- Editorial
- Oxford University Press
- Citado
- 255 citas · más que el 100% de estudios similares · 24.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 25 trabajos
- Acceso
- De pago
- Áreas de investigación
- Bone health and osteoporosis research · Vitamin D Research Studies · Nutrition, Genetics, and Disease
- Palabras clave
- vitamin D receptor, BsmI polymorphism, bone loss, postmenopausal women, calcium supplementation, bone mineral density, genetic susceptibility, calcium metabolism, menopause duration, osteoporosis, femoral neck, spine, radius
- MeSH
- radius, femur neck, lumbar vertebrae, humans, osteoporosis, postmenopausal, calcium, dietary, receptors, calcitriol, dna primers, absorptiometry, photon, cohort studies, longitudinal studies, base sequence, aging, bone density, genotype, alleles, molecular sequence data, aged, middle aged, female
4 autores
- Elizabeth A. Krall🇺🇸Tufts University
- P. Parry
- Jay B. Lichter
- Bess Dawson‐Hughes🇺🇸 · autor de correspondenciaTufts University
Resumen
El texto original del estudio, en el idioma en que se publicó.
A genetic marker for the 1,25-dihydroxyvitamin D receptor (VDR) is reported to account for much of the heritable component of bone density. It is not known whether VDR genotype influences bone accretion or loss, or how it is related to calcium metabolism. The VDR genotype was determined in 229 healthy postmenopausal women who previously participated in a calcium trial. VDR alleles were designated according to presence (b) or absence (B) of the BsmI restriction enzyme cutting site. There were 83 bb, 102 Bb, and 44 BB individuals. Two-thirds of the women took 500 mg of calcium supplement (mean calcium intake = 892 mg/day) and one-third a placebo (mean = 376 mg/day). Bone mineral density (BMD) at the femoral neck, spine, and radius were measured by dual- and single-photon absorptiometry at baseline and after 1 and 2 years. Among women more than 10 years postmenopausal, those with the BB genotype had the lowest femoral neck BMD. Rates of bone loss over 2 years were greater in the BB group at all sites (e.g., at the femoral neck, bb, 0.45 +/- 0.43; Bb, -0.01 +/- 0.40; BB, -0.99 +/- 0.50%/year; BB vs. bb, p = 0.01), and this trend was found both in women or = 10 years (radius, bb, -0.71 +/- 0.41; Bb, 0.08 +/- 0.39; BB, -1.41 +/- 0.49% per year; BB vs. Bb, p < 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.