Creatine supplementation in chronic heart failure increases skeletal muscle creatine phosphate and muscle performance
Gordon A, Hultman E, Kaijser L, Kristjansson S, Rolf CJ, Nyquist O, Sylvén C
Cardiovascular research · 103 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Hjärt-Lungfonden
- Gobierno
- Vetenskapsrådet
Según 2 financiadores declarados.
Publicación
- Publicado
- 1995-09-01 · Cardiovasc Res · vol. 30 · número 3 · págs. 413–418
- Editorial
- Oxford University Press
- Citado
- 195 citas · más que el 82% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Cardiovascular and exercise physiology · Biochemical effects in animals
- Palabras clave
- creatine supplementation, chronic heart failure, phosphocreatine, skeletal muscle, muscle strength, physical endurance, ejection fraction, exercise performance, peak torque
- MeSH
- muscle, skeletal, humans, chronic disease, creatine, phosphocreatine, radionuclide angiography, cardiac output, administration, oral, double-blind method, physical endurance, adult, aged, middle aged, male, heart failure
7 autores
- A. Gordon🇸🇪 · autor de correspondenciaKarolinska Institutet
- Erik Hultman🇸🇪Karolinska Institutet
- L. Kaijser🇸🇪Karolinska Institutet
- Sveinbjörn Kristjánsson🇸🇪Karolinska Institutet
- Christer Rolf🇸🇪Karolinska Institutet
- O. Nyquist🇸🇪Karolinska Institutet
- Christer Sylvén🇸🇪Karolinska Institutet
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Cardiac creatine levels are depressed in chronic heart failure. Oral supplementation of creatine to healthy volunteers has been shown to increase physical performance.
Aim
To evaluate the effects of creatine supplementation on ejection fraction, symptom-limited physical endurance and skeletal muscle strength in patients with chronic heart failure.
Methods
With a double-blind, placebo-controlled design 17 patients (age 43-70 years, ejection fraction < 40) were supplemented with creatine 20 g daily for 10 days. Before and on the last day of supplementation ejection fraction was determined by radionuclide angiography as was symptom-limited 1-legged knee extensor and 2-legged exercise performance on the cycle ergometer. Muscle strength as unilateral concentric knee extensor performance (peak torque, Nm at 180 degrees/s) was also evaluated. Skeletal muscle biopsies were taken for the determination of energy-rich phosphagens.
Results
Ejection fraction at rest and at work did not change. Performance before creatine supplementation did not differ between placebo and creatine groups. While no change was seen in the placebo group compared to baseline, creatine supplementation increased skeletal muscle total creatine and creatine phosphate by 17 +/- 4% (P < 0.05) and 12 +/- 4% (P < 0.05), respectively. Increments were seen only in patients with < 140 mmol total creatine/kg d.w. (P < 0.05). One-legged performance (21%, P < 0.05), 2-legged performance (10%, P < 0.05), and peak torque, Nm (5%, P < 0.05) increased. Both peak torque and 1-legged performance increased linearly with increased skeletal muscle phosphocreatine (P < 0.05). The increments in 1-legged, 2-legged and peak torque were significant compared to the placebo group, (P < 0.05).
Conclusions
One week of creatine supplementation to patients with chronic heart failure did not increase ejection fraction but increased skeletal muscle energy-rich phosphagens and performance as regards both strength and endurance. This new therapeutic approach merits further attention.
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