Chronic effects of habitual caffeine consumption on laboratory and ambulatory blood pressure levels
James JE
Journal of cardiovascular risk · 37 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1994-08-01 · J Cardiovasc Risk · vol. 1 · número 2 · págs. 159–164
- Editorial
- SAGE Publishing
- Citado
- 53 citas · más que el 82% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 30 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Blood Pressure and Hypertension Studies · Sodium Intake and Health
- Palabras clave
- caffeine, habitual caffeine consumption, blood pressure, ambulatory blood pressure, heart rate, pressor response, caffeine abstinence, cardiovascular risk, normotensive subjects
- MeSH
- humans, caffeine, blood pressure monitoring, ambulatory, analysis of variance, cross-over studies, double-blind method, feeding behavior, blood pressure, heart rate, stimulation, chemical, time factors, adolescent, adult, middle aged, female, male
1 autor
- Jack E. James🇦🇺 · autor de correspondenciaLa Trobe University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Uncertainty continues to surround the role of habitual caffeine consumption as a cardiovascular risk factor. The present study examined the effects of moderate caffeine intake on 24h blood pressure and heart rate in normotensive men and women.
Methods
A double-blind, placebo-controlled, crossover design with counterbalancing was used, in which 36 healthy men and women participated in four experimental conditions involving the ingestion of placebo or caffeine three times daily for 6 days, followed by a seventh ('challenge') day of placebo or caffeine ingestion.
Results
When caffeine was consumed on the challenge day, blood pressure was found to be elevated immediately after caffeine ingestion and was either unchanged or decreased (hypotensive effect) after a period of abstinence from the drug. Some diminution of the peak pressor effects was found when participants ingested caffeine after habitual use of the drug (6.0/5.2 mmHg) compared with when they had been abstinent before the challenge day (7.7/6.8 mmHg). This diminution in the reaction was comparatively small, however, and pressor effects persisted on caffeine-challenge days even when caffeine was consumed on preceding days.
Conclusion
Habitual consumption diminished, but did not eliminate, the pressor effects of caffeine. Considering the almost universal consumption of caffeine beverages, the persistent pressor effects of the drug could have important implications for cardiovascular health.
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