Lipoprotein-cholesterol responses in healthy infants fed defined diets from ages 1 to 12 months: comparison of diets predominant in oleic acid versus linoleic acid, with parallel observations in infants fed a human milk-based diet
Mize CE, Uauy R, Kramer R, Benser M, Allen S, Grundy SM
Journal of lipid research · 19 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HL-292-52)
Según 2 financiadores declarados.
Publicación
- Publicado
- 1995-06-01 · J Lipid Res · vol. 36 · número 6 · págs. 1178–1187
- Editorial
- Elsevier BV
- Citado
- 42 citas · más que el 92% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Infant Nutrition and Health · Cholesterol and Lipid Metabolism
- Palabras clave
- infant nutrition, dietary fatty acids, oleic acid, linoleic acid, polyunsaturated fatty acids, monounsaturated fatty acids, cholesterol, LDL cholesterol, HDL cholesterol, total cholesterol, breast milk, infant formula, complementary foods, plasma lipids, cholesterol-lowering effect
- MeSH
- humans, dietary fats, linoleic acids, linoleic acid, oleic acids, oleic acid, triglycerides, prospective studies, double-blind method, infant food, infant, cholesterol, ldl, cholesterol, hdl, cholesterol, vldl
6 autores
- Charles E. Mize🇺🇸The University of Texas Southwestern Medical Center
- Ricardo D. Uauy🇺🇸The University of Texas Southwestern Medical Center
- Robert E Kramer🇺🇸The University of Texas Southwestern Medical Center
- Margareta Benser🇺🇸The University of Texas Southwestern Medical Center
- S. Allen🇺🇸The University of Texas Southwestern Medical Center
- Scott M. Grundy🇺🇸The University of Texas Southwestern Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
A prospective study in healthy infants predefining both diet fatty acid and cholesterol, from birth to age 1 year, compared response of cholesterol fractions in three groups: random assignment to 1) monounsaturated-(Hi-Mono) (n = 20), or 2) polyunsaturated-(Hi-Poly) (n = 22) fatty acid-enriched diets, or 3) non-randomized selection to breast feeding (Human Milk) (n = 25). In each group, designated weaning foods and supplements maintained fatty acid and cholesterol intake similar to that of each group's defined formulas, with long-term compliance confirmed by plasma phospholipid fatty acid concentrations. By 12 months, total cholesterol was significantly lower in the Hi-Poly group compared to either of the other groups (P < 0.05). Low density lipoprotein (LDL)- and high density lipoprotein (HDL)-cholesterol concentrations were significantly lower by 12 months in the Hi-Poly group, compared to the Hi-Mono groups. However, at the earlier 4-month interval, total cholesterol and LDL-cholesterol in both Hi-Mono and Hi-Poly groups were not different from each other, although each was significantly lower than the parallel Human Milk-group (P < 0.05). The Hi-Mono group increased gradually in total and LDL-cholesterol such that, after 12 months' feedings, all lipid fractions of this Hi-Mono group were no different from those of the Human Milk group. In independent group comparisons, there were no significant differences in HDL-cholesterol concentrations after 4 and 9 months on these diets. Independent of diet, HDL-cholesterol showed a falling trend as an overall time-effect across all groups (P < 0.001). These data suggest that prolonged feeding of a diet enriched in polyunsaturated acids in early infancy has a significant cholesterol-lowering effect compared to monounsaturates. These differences in total, LDL-, and HDL-cholesterol plasma concentrations between polyunsaturates and monounsaturates were not significantly evident until feedings had continued for a year.
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