Role of smoking in the U-shaped relation of cholesterol to mortality in men. The Framingham Study
D'Agostino RB, Belanger AJ, Kannel WB, Higgins M
American journal of epidemiology · 29 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (R01-HL-40423-5); National Heart, Lung, and Blood Institute (N01-HV-92922); National Heart, Lung, and Blood Institute (N01-HV52971)
Según 3 financiadores declarados.
Publicación
- Publicado
- 1995-05-01 · Am J Epidemiol · vol. 141 · número 9 · págs. 822–827
- Editorial
- Oxford University Press
- Citado
- 46 citas · más que el 90% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Cholesterol and Lipid Metabolism · Cardiovascular Health and Risk Factors
- Palabras clave
- total cholesterol, cigarette smoking, U-shaped relationship, all-cause mortality, cancer mortality, coronary heart disease mortality, hypocholesterolemia, men, Framingham Heart Study, alcohol consumption, cardiovascular disease
- MeSH
- humans, neoplasms, coronary disease, cholesterol, mortality, cause of death, proportional hazards models, risk factors, cohort studies, alcohol drinking, smoking, adult, aged, middle aged, massachusetts, male
4 autores
- Ralph B. D’Agostino🇺🇸 · autor de correspondenciaBoston University
- Albert J. Belanger🇺🇸Boston University
- William B. Kannel🇺🇸Boston University
- MILLICENT W. HIGGINS🇺🇸National Heart, Lung, and Blood Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Elevated mortality has been reported at extremes of the serum total cholesterol distribution, with increased coronary mortality reported at high total cholesterol levels and increased cancer and non-cardiovascular/non-cancer mortality at low total cholesterol levels. The authors used data collected on 1,959 males aged 35-69 years from the fourth Framingham Study examination to analyze the relations between total serum cholesterol levels and 409 coronary deaths, 325 cancer deaths, and 534 other deaths for a 32-year follow-up. Age- and risk factor-adjusted Cox regressions were computed. Nonlinear (U-shaped) relations were investigated with the use of quadratic regression and with dummy variables using the 160-199 mg/dl group as the comparison group. Subset analyses investigated the relation in smokers and men who drank > or = 14 alcoholic drinks per week. All analyses were repeated removing those with existing cardiovascular disease and cancer and those who died during the first 5 years of follow-up. A significant U-shaped relation with all-cause mortality was noted, as were an inverse relation to cancer mortality and a monotonic increasing relation with coronary disease mortality. In subset analyses, the association of low serum cholesterol (< 160 mg/dl) with cancer mortality was observed in men who smoked cigarettes. Compared with the 160-199 mg/dl group, the relative risk was 3.72 (p = 0.0001, 95% confidence interval 1.91-7.25). Studies of the relation of low total serum cholesterol levels, cigarette smoking, and cancer are needed.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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