Rates of bone loss in postmenopausal women randomly assigned to one of two dosages of vitamin D
Dawson-Hughes B, Harris SS, Krall EA, Dallal GE, Falconer G, Green CL
The American journal of clinical nutrition · 131 citas
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- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Marcadores de salud y funcionamiento
Quién lo pagó
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Publicación
- Publicado
- 1995-05-01 · Am J Clin Nutr · vol. 61 · número 5 · págs. 1140–5
- Editorial
- National Institutes of Health
- Citado
- 60 citas · más que el 89% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Vitamin K Research Studies
- Palabras clave
- vitamin D supplementation, bone loss, postmenopausal women, femoral neck bone mineral density, seasonal variation, 25-hydroxyvitamin D3, serum osteocalcin, calcium supplementation, RDA, osteoporosis prevention
- MeSH
- bone and bones, femur neck, spine, humans, osteoporosis, postmenopausal, calcifediol, vitamin d, osteocalcin, diet, double-blind method, seasons, nutritional requirements, bone density, dose-response relationship, drug, aged, middle aged, female
6 autores
- Bess Dawson‐Hughes🇺🇸Tufts University
- S S Harris🇺🇸Tufts University
- Elizabeth A. Krall🇺🇸Tufts University
- Gerard E. Dallal🇺🇸Tufts University
- G Falconer🇺🇸Tufts University
- CL Green🇺🇸Tufts University
Resumen
El texto original del estudio, en el idioma en que se publicó.
We conducted a study to determine whether increasing vitamin D intake above the recommended dietary allowance (RDA) of 5.0 micrograms (200 IU)/d reduces bone loss in healthy postmenopausal women residing at latitude 42 degrees N. In this double-blind, randomized 2-y trial, we enrolled 247 healthy ambulatory postmenopausal women who consumed an average of 2.5 micrograms (100 IU) vitamin D/d in their usual diets. The women were given either 2.5 micrograms (100 IU) or 17.5 micrograms (700 IU) vitamin D/d. All women received 500 mg supplemental calcium per day as citrate malate. Duplicate hip and spine and single whole-body scans were performed by dual-energy x-ray absorptiometry at 6-mo intervals selected to flank the periods when 25-hydroxycholecalciferol (calcidiol) concentrations are highest (summer/fall) and lowest (winter/spring). Plasma calcidiol and serum osteocalcin were measured in these seasons in year 1. Both treatment groups lost bone mineral density from the femoral neck, but the 17.5-micrograms group lost less than (-1.06 +/- 0.34%; mean +/- SE) the 2.5-micrograms group (-2.54 +/- 0.37%, P = 0.003). Seventy percent of the benefit each year occurred in winter/spring and 30% in summer/fall. Changes in spinal and whole-body bone densities did not differ by treatment group and were minimal after 2 y. Serum osteocalcin and plasma calcidiol (2.5-micrograms group only) fluctuated with season. In conclusion, in healthy, calcium-supplemented, postmenopausal women residing at latitude 42 degrees N, an intake of 5.0 micrograms (200 IU) vitamin D/d is sufficient to limit bone loss from the spine and whole body but it is not adequate to minimize bone loss from the femoral neck.(ABSTRACT TRUNCATED AT 250 WORDS)
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