Controlled trial of fish oil for regression of human coronary atherosclerosis. HARP Research Group
Sacks FM, Stone PH, Gibson CM, Silverman DI, Rosner B, Pasternak RC
Journal of the American College of Cardiology · 143 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Center for Research Resources (RR02635); National Heart, Lung, and Blood Institute (R01 HL36392)
Según 4 financiadores declarados.
Publicación
- Publicado
- 1995-06-01 · J Am Coll Cardiol · vol. 25 · número 7 · págs. 1492–1498
- Editorial
- Elsevier BV
- Citado
- 216 citas · más que el 95% de estudios similares · 4.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 65 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Lipoproteins and Cardiovascular Health · Aquaculture Nutrition and Growth
- Palabras clave
- fish oil, omega-3 fatty acids, coronary artery disease, eicosapentaenoic acid, triglyceride lowering, coronary artery stenosis, olive oil placebo, adipose tissue fatty acid composition, antiatherogenic effects
- MeSH
- adipose tissue, humans, cholesterol, dietary fats, unsaturated, fatty acids, omega-3, fatty acids, triglycerides, lipoproteins, plant oils, coronary angiography, time factors, middle aged, female, male, coronary artery disease, cardiac catheterization, olive oil
6 autores
- Frank M. Sacks🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
- Peter Howard Stone🇺🇸Brigham and Women's Hospital; Harvard University
- Charles Michael Gibson🇺🇸Brigham and Women's Hospital; Harvard University
- David I. Silverman🇺🇸Harvard University
- BERNARD A. ROSNER🇺🇸Brigham and Women's Hospital; Harvard University
- Richard C. Pasternak🇺🇸Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
This randomized clinical trial tested whether fish oil supplements can improve human coronary atherosclerosis.
Background
Epidemiologic studies of populations whose intake of oily fish is high, as well as laboratory studies of the effects of the polyunsaturated fatty acids in fish oil, support the hypothesis that fish oil is antiatherogenic.
Methods
Patients with angiographically documented coronary heart disease and normal plasma lipid levels were randomized to receive either fish oil capsules (n = 31), containing 6 g of n-3 fatty acids, or olive oil capsules (n = 28) for an average duration of 28 months. Coronary atherosclerosis on angiography was quantified by computer-assisted image analysis.
Results
Mean (+/- SD) baseline characteristics were age 62 +/- 7 years, plasma total cholesterol concentration 187 +/- 31 mg/dl (4.83 +/- 0.80 mmol/liter) and triglyceride levels 132 +/- 70 mg/dl (1.51 +/- 0.80 mmol/liter). Fish oil lowered triglyceride levels by 30% (p = 0.007) but had no significant effects on other plasma lipoprotein levels. At the end of the trial, eicosapentaenoic acid in adipose tissue samples was 0.91% in the fish oil group compared with 0.20% in the control group (p 0.17 mm, or > 2.6%.
Conclusions
Fish oil treatment for 2 years does not promote major favorable changes in the diameter of atherosclerotic coronary arteries.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.