Effects of fish oil fatty acids on low density lipoprotein size, oxidizability, and uptake by macrophages
Suzukawa M, Abbey M, Howe PR, Nestel PJ
Journal of lipid research · 115 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1995-03-01 · J Lipid Res · vol. 36 · número 3 · págs. 473–484
- Editorial
- Elsevier BV
- Citado
- 185 citas · más que el 99% de estudios similares · 11.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 75 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Edible Oils Quality and Analysis
- Palabras clave
- fish oil fatty acids, corn oil, low-density lipoprotein, LDL oxidation, LDL particle size, macrophage uptake, copper-induced oxidation, TBARS, plasma triglycerides, LDL cholesterol, hypertension, atherosclerosis, HDL cholesterol
- MeSH
- macrophages, humans, arteriosclerosis, hypertension, copper, thiobarbituric acid reactive substances, dietary fats, unsaturated, corn oil, fatty acids, omega-3, triglycerides, lipoproteins, ldl, fish oils, cross-over studies, double-blind method, biological transport, active, oxidation-reduction, particle size, aged, middle aged, female, male, in vitro techniques
4 autores
- Michio Suzukawa🇦🇺Commonwealth Scientific and Industrial Research Organisation
- Mavis Abbey🇦🇺Commonwealth Scientific and Industrial Research Organisation
- Peter R.C. Howe🇦🇺Commonwealth Scientific and Industrial Research Organisation
- Paul John Nestel🇦🇺Commonwealth Scientific and Industrial Research Organisation
Resumen
El texto original del estudio, en el idioma en que se publicó.
The effect of fish oil and corn oil supplementation on plasma lipids and lipoproteins and on low density lipoprotein (LDL) oxidation was examined in 20 treated hypertensive subjects. The randomized double-blind crossover study consisted of two 6-week interventions with 4 g/day of a highly purified fish oil or corn oil. Fish oil significantly (-24%, P < 0.01) reduced plasma triglyceride, and increased LDL-cholesterol (+6%, P < 0.01 compared to corn oil). LDL particles were larger (P < 0.01) after fish oil compared to baseline and LDL size was inversely correlated with plasma triglyceride (P < 0.001) both before and after fish oil supplementation, and positively correlated with high density lipoprotein cholesterol (P < 0.01). Fish oil reduced lag time before onset of copper-induced LDL oxidation (-25%, P < 0.001) and significantly increased production of thiobarbituric acid-reactive substances (TBARS) during oxidation, compared with corn oil. Corn oil had no significant effect on lag time and oxidation rate. Fish oil increased macrophage uptake of copper-oxidized LDL and of macrophage-modified LDL. Corn oil was without effect. Additionally, macrophages that were supplemented with fish oil fatty acids in vitro displayed a significantly (P < 0.001) higher capacity to oxidize LDL than either control cells or cells supplemented with corn oil fatty acids. We conclude that from the standpoint of atherosclerosis, fish oil fatty acids adversely raise the susceptibility of LDL to copper-induced and macrophage-mediated oxidation but that the increase in plasma LDL cholesterol concentration reflects an increase in size that may be favorable.
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