Lack of blood pressure effect with calcium and magnesium supplementation in adults with high-normal blood pressure. Results from Phase I of the Trials of Hypertension Prevention (TOHP). Trials of Hypertension Prevention (TOHP) Collaborative Research Group
Yamamoto ME, Applegate WB, Klag MJ, Borhani NO, Cohen JD, Kirchner KA, Lakatos E, Sacks FM, Taylor JO, Hennekens CH
Annals of epidemiology · 48 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Pittsburgh
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HL-37924); National Heart, Lung, and Blood Institute (HL37852); National Heart, Lung, and Blood Institute (HL 37904); National Heart, Lung, and Blood Institute (HL-37854); National Heart, Lung, and Blood Institute (HL-37872); National Heart, Lung, and Blood Institute (HL37906); National Heart, Lung, and Blood Institute (HL37853)
Según 4 financiadores declarados.
Publicación
- Publicado
- 1995-03-01 · Ann Epidemiol · vol. 5 · número 2 · págs. 96–107
- Editorial
- Elsevier BV
- Citado
- 76 citas · más que el 89% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 73 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Blood Pressure and Hypertension Studies · Sodium Intake and Health · Magnesium in Health and Disease
- Palabras clave
- calcium supplementation, magnesium supplementation, high-normal blood pressure, diastolic blood pressure, hypertension prevention, dietary supplements, urinary calcium, urinary sodium, subgroup analysis, women
- MeSH
- humans, hypertension, calcium carbonate, magnesium, prognosis, administration, oral, double-blind method, patient compliance, blood pressure, adult, middle aged, female, male, white people, black people
10 autores
- Monica E. Yamamoto🇺🇸 · autor de correspondenciaUniversity of Pittsburgh
- William B. Applegate
- Michael J. Klag🇺🇸Johns Hopkins University
- Nemat O. Borhani🇺🇸Brigham and Women's Hospital; Harvard University
- Jerome D. Cohen🇺🇸Saint Louis University
- Kent A. Kirchner🇺🇸University of Mississippi Medical Center
- Edward Lakatos🇺🇸National Institutes of Health; National Heart, Lung, and Blood Institute
- Frank M. Sacks🇺🇸Brigham and Women's Hospital
- James O. Taylor
- Charles H. Hennekens🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Phase I of the Trials of Hypertension Prevention (TOHP) was a randomized, multicenter investigation that included double-blind, placebo-controlled testing of calcium and magnesium supplementation among 698 healthy adults (10.5% blacks and 31% women) aged 30 to 54 years with high-normal diastolic blood pressure (DBP) (80 to 89 mm Hg). Very high compliance (94 to 96% by pill counts) with daily doses of 1 g of calcium (carbonate), 360 mg of magnesium (diglycine), or placebos was corroborated for the active supplements by significant net increases in all urine and serum compliance measures in white men and for urine compliance measures in white women. Overall, neither calcium nor magnesium produced significant changes in blood pressure at 3 and 6 months. Analyses stratified by baseline intakes of calcium, magnesium, sodium, or initial blood pressures also showed no effect of supplementation. These analyses suggested that calcium supplementation may have resulted in a DBP decrease in white women and that response modifiers in this subgroup might have included lower initial urinary calcium levels, urinary sodium levels, or lower body mass index. However, overall analyses indicated that calcium and magnesium supplements are unlikely to lower blood pressure in adults with high-normal DBP. The subgroup analyses, useful to formulate hypotheses, raise the possibility of a benefit to white women, which requires testing in future trials.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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