Subjective and cardiovascular responses to nicotine combined with caffeine during rest and casual activity
Perkins KA, Sexton JE, Stiller RL, Fonte C, DiMarco A, Goettler J, Scierka A
Psychopharmacology · 29 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Drug Abuse
- Gobierno
- NIDA NIH HHS
- Subvenciones
- National Institute on Drug Abuse (DA04174); National Institute on Drug Abuse (DA-05807)
Según 2 financiadores declarados.
Publicación
- Publicado
- 1994-01-01 · Psychopharmacology (Berl) · vol. 113 · número 3-4 · págs. 438–444
- Editorial
- Springer Science+Business Media
- Citado
- 44 citas · más que el 89% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Smoking Behavior and Cessation · Nicotinic Acetylcholine Receptors Study
- Palabras clave
- nicotine, caffeine, subjective arousal, mood, cardiovascular effects, heart rate, blood pressure, physical activity, smoking, coffee consumption, additive drug effects, sex differences
- MeSH
- humans, nicotine, caffeine, electrocardiography, exercise, smoking, affect, arousal, blood pressure, heart rate, bicycling, rest, adult, female, male, hemodynamics
7 autores
- Kenneth A. Perkins🇺🇸University of Pittsburgh
- Joan E. Sexton🇺🇸University of Pittsburgh
- Richard L. Stiller🇺🇸Children's Hospital of Pittsburgh
- Carolyn A. Fonte🇺🇸University of Pittsburgh
- Amy DiMarco🇺🇸University of Pittsburgh
- Jennifer Goettler🇺🇸University of Pittsburgh
- Annette M. Scierka🇺🇸Children's Hospital of Pittsburgh
Resumen
El texto original del estudio, en el idioma en que se publicó.
Although nicotine and caffeine have separately been shown to acutely increase subjective arousal, their combined effects are unclear. Furthermore, their effects during casual physical activity, the condition under which individuals usually experience nicotine and caffeine, are unknown. Smokers who were regular coffee drinkers (n = 19, 9 males, 10 females) participated in eight morning sessions, involving nicotine/placebo, caffeine/no caffeine, and rest/physical activity (i.e. 2 x 2 x 2 within-subjects design). Nicotine (15 micrograms/kg) or placebo was given via measured-dose nasal spray intermittently after consumption of decaf coffee with or without added caffeine (5 mg/kg), followed by subjective [Profile of Mood States (POMS), Stress-Arousal Checklist, visual analog scales] and cardiovascular (heart rate, blood pressure) measures. Casual physical activity was standardized by low-intensity bicycle riding while sitting comfortably. Results indicated significant subjective and cardiovascular effects of nicotine and caffeine individually, with the combination of nicotine and caffeine generally producing additive or greater than additive effects for each measure. However, activity mediated some of the subjective effects of nicotine, as nicotine appeared to be "stimulating" during rest but not during activity. There were no differences between males and females. These findings suggest that nicotine per se and caffeine generally have additive subjective and cardiovascular effects, and that nicotine may influence subjective stimulation differentially depending on whether a smoker is resting or engaged in casual activity.
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