Dietary substitution with an alpha-linolenic acid-rich vegetable oil increases eicosapentaenoic acid concentrations in tissues
Mantzioris E, James MJ, Gibson RA, Cleland LG
The American journal of clinical nutrition · 165 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1994-06-01 · Am J Clin Nutr · vol. 59 · número 6 · págs. 1304–1309
- Editorial
- Elsevier BV
- Citado
- 284 citas · más que el 99% de estudios similares · 9.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Aquaculture Nutrition and Growth · Edible Oils Quality and Analysis
- Palabras clave
- alpha-linolenic acid, linseed oil, eicosapentaenoic acid, docosahexaenoic acid, fish oil supplementation, dietary omega-3 fatty acids, linoleic acid, plasma phospholipids, tissue fatty acid composition, Western diet
- MeSH
- humans, cholesterol esters, dietary fats, alpha-linolenic acid, eicosapentaenoic acid, fatty acids, phospholipids, fish oils, plant oils, anthropometry, energy intake, adult, male
4 autores
- Evangeline Mantzioris🇦🇺 · autor de correspondenciaRoyal Adelaide Hospital
- MJ James🇦🇺Royal Adelaide Hospital; Flinders Medical Centre
- Robert Alan Gibson🇦🇺Royal Adelaide Hospital; Flinders Medical Centre
- LG Cleland🇦🇺Royal Adelaide Hospital; Flinders Medical Centre
Resumen
El texto original del estudio, en el idioma en que se publicó.
Thirty healthy male volunteers were randomly allocated into two dietary treatment groups. The flaxseed group (n = 15) maintained a diet high in alpha-linolenic acid (alpha-LA; 18:3n-3) and low in linoleic acid (LA; 18:2n-6) by using a flaxseed oil and spread that are high in alpha-LA. The control group (n = 15) maintained a diet high in LA and low in alpha-LA, typifying a Western diet. Both groups maintained their diets for 4 wk, followed by another 4-wk period in which they supplemented the diets with fish oil [1.62 g eicosapentaenoic acid (EPA, 20:5n-3) daily and 1.08 g docosahexaenoic acid (DHA, 22:6n-3) daily] in a triglyceride form. The flaxseed oil-containing diet resulted in significant increases in alpha-LA concentrations in the plasma phospholipid, cholesteryl ester, and triglyceride fractions (eightfold increase) and neutrophil phospholipids (50% increase). EPA concentrations increased by 2.5-fold in the plasma lipid fractions and neutrophil phospholipids. After fish-oil supplementation EPA concentrations increased in parallel in both dietary groups, remaining higher in the flaxseed group for both the plasma lipid fractions and neutrophil phospholipids. The results indicate that alpha-LA-rich vegetable oils can be used in a domestic setting (in conjunction with a background diet low in LA) to elevate EPA in tissues to concentrations comparable with those associated with fish-oil supplementation.
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