Cardiovascular effects of Atenolol, scopolamine and their combination on healthy men in Finnish sauna baths
Kukkonen-Harjula K, Oja P, Vuori I, Pasanen M, Lange K, Siitonen S, Metsä-Ketelä T, Vapaatalo H
European journal of applied physiology and occupational physiology · 10 citas
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- Ensayo controlado aleatorizado (indexado por PubMed)
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Publicación
- Publicado
- 1994-01-01 · Eur J Appl Physiol Occup Physiol · vol. 69 · número 1 · págs. 10–15
- Editorial
- Springer Science+Business Media
- Citado
- 20 citas · más que el 16% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 19 trabajos
- Acceso
- De pago
- Áreas de investigación
- Thermoregulation and physiological responses · Heart Rate Variability and Autonomic Control · Cardiovascular and exercise physiology
- Palabras clave
- atenolol, scopolamine, sauna bathing, heat stress, cardiovascular strain, heart rate, blood pressure, plasma norepinephrine, epinephrine, thromboxane B2, autonomic nervous system, beta-adrenergic blockade, anticholinergic agents, drug pretreatment
- MeSH
- cardiovascular system, humans, epinephrine, norepinephrine, atenolol, scopolamine, drug combinations, steam bath, administration, oral, blood pressure, heart rate, adult, male, cardiovascular physiological phenomena
8 autores
- Katriina Kukkonen-Harjula🇫🇮Urho Kaleva Kekkonen Institute
- Pekka Oja🇫🇮Urho Kaleva Kekkonen Institute
- ILKKA M. VUORI🇫🇮Urho Kaleva Kekkonen Institute
- Matti E. Pasanen🇫🇮Urho Kaleva Kekkonen Institute
- Kai Henrik Wiborg Lange🇫🇮Urho Kaleva Kekkonen Institute
- Simo Siitonen🇫🇮Urho Kaleva Kekkonen Institute
- T. Mets�-Ketel�🇫🇮Tampere University; University of Tampere
- Heikki Vapaatalo🇫🇮Tampere University; University of Tampere
Resumen
El texto original del estudio, en el idioma en que se publicó.
Indicators of cardiovascular strain were studied in 12 healthy young men under the influence of drugs affecting the autonomic nervous system during the course of taking a sauna bath. There were four bath sessions: one without a drug (control) and three with drug pretreatment (Atenolol 50 mg or Scopolamine 0.3 mg or their combination taken orally 2 h before the bath). The time spent in the hot room depended on the subjective rating of heat stress. Its mean duration at a temperature of 88 degrees C (dry bulb) was 22 (range 14-33) min and did not differ significantly among the sessions. In the Atenolol experiment the mean resting heart rate before the bath was significantly lower (P < 0.001, ANOVA of repeated measures) than in the other experiments. The increase in heart rate per minute of heat exposure was significantly lower (P < 0.001) in the Atenolol experiment and higher (P = 0.017) in the Scopolamine experiment than in the other experiments. The systolic blood pressure increased more slowly (P = 0.004) and the diastolic pressure decreased less (P = 0.02) in the Atenolol experiment than in the other experiments. Heart rate and blood pressure returned to their initial levels during the 30-min recovery after the heat exposure. The plasma noradrenaline concentrations increased approximately twofold during all of the bath sessions, whereas the plasma adrenaline and serum thromboxane B2 concentrations showed no consistent alterations. A small oral dose of Scopolamine alone or in combination with Atenolol produced no marked cardiovascular strain in healthy men during a sauna bath.
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