Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas
Anti M, Armelao F, Marra G, Percesepe A, Bartoli GM, Palozza P, Parrella P, Canetta C, Gentiloni N, De Vitis I
Gastroenterology · 110 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1994-12-01 · Gastroenterology · vol. 107 · número 6 · págs. 1709–1718
- Editorial
- Elsevier BV
- Citado
- 194 citas · más que el 98% de estudios similares · 7.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Inflammatory mediators and NSAID effects · Antioxidant Activity and Oxidative Stress
- Palabras clave
- fish oil supplementation, colorectal adenoma, dose-response relationship, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, alpha-tocopherol, rectal mucosa, colon cancer risk, long-term treatment
- MeSH
- intestinal mucosa, rectum, humans, adenomatous polyposis coli, vitamin e, docosahexaenoic acids, eicosapentaenoic acid, fish oils, analysis of variance, double-blind method, cell division, aged, middle aged, female, male
11 autores
- Marcello Anti🇮🇹Università Cattolica del Sacro Cuore
- Franco Armelao🇮🇹Università Cattolica del Sacro Cuore
- Giancarlo Marra🇮🇹Università Cattolica del Sacro Cuore
- Antonio Percesepe🇮🇹Università Cattolica del Sacro Cuore
- Gianna Maria Bartoli🇮🇹University of Rome Tor Vergata
- Paola Palozza🇮🇹Università Cattolica del Sacro Cuore
- Paola Parrella🇮🇹Università Cattolica del Sacro Cuore
- Ciro Canetta🇮🇹Università Cattolica del Sacro Cuore
- Nicola Gentiloni🇮🇹Università Cattolica del Sacro Cuore
- I. De Vitis🇮🇹Università Cattolica del Sacro Cuore
- Antonio Gasbarrini🇮🇹Università Cattolica del Sacro Cuore
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/aims
Fish oil supplementation can reduce cytokinetic anomalies in the flat rectal mucosa of patients with sporadic colorectal adenoma. This study attempted to identify an optimum dose for fish oil supplementation and evaluate the persistence of its effects during long-term administration.
Methods
In a double-blind study, 60 patients with sporadic adenomas received 2.5, 5.1, or 7.7 g of fish oil per day or placebo for 30 days. [3H]thymidine autoradiographic labeling indices were calculated in flat rectal mucosal biopsy specimens collected before and after supplementation. In a subsequent study, 15 patients with polyps received 2.5 g of fish oil per day. Proliferative parameters, mucosal fatty acids, and mucosal and plasma alpha-tocopherol levels were evaluated before, during, and after 6 months of supplementation.
Results
Mean proliferative indices and mucosal arachidonic acid levels decreased significantly (and to similar degrees) in all treated groups, whereas mucosal eicosapentaenoic and docosahexaenoic acid levels increased. Significantly reduced proliferation was observed only in patients with abnormal baseline patterns. These effects persisted during long-term, low-dose treatment. A transient reduction in mucosal (but not plasma) alpha-tocopherol levels was observed after 1 month of treatment. Side effects were insignificant.
Conclusions
Low-dose fish oil supplementation has short-term and long-term normalizing effects on the abnormal rectal proliferation patterns associated with increased colon cancer risk.
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