Oral magnesium intake reduces permanent hearing loss induced by noise exposure
Attias J, Weisz G, Almog S, Shahar A, Wiener M, Joachims Z, Netzer A, Ising H, Rebentisch E, Guenther T
American journal of otolaryngology · 69 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1994-01-01 · Am J Otolaryngol · vol. 15 · número 1 · págs. 26–32
- Editorial
- Elsevier BV
- Citado
- 133 citas · más que el 56% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 23 trabajos
- Acceso
- De pago
- Áreas de investigación
- Hearing, Cochlea, Tinnitus, Genetics · Noise Effects and Management · Magnesium in Health and Disease
- Palabras clave
- magnesium supplementation, noise-induced hearing loss, permanent threshold shift, military education, magnesium aspartate, hearing protection
- MeSH
- humans, hearing loss, noise-induced, aspartic acid, administration, oral, multivariate analysis, double-blind method, auditory threshold, noise, occupational, adolescent, military personnel, israel, male
10 autores
- Joseph Attias🇮🇱🇩🇪 · autor de correspondenciaRambam Health Care Campus; Israel Defense Forces Medical Corps; Freie Universität Berlin
- Giora Weisz🇮🇱🇩🇪Rambam Health Care Campus; Israel Defense Forces Medical Corps; Freie Universität Berlin
- Shlomo Almog🇮🇱🇩🇪Rambam Health Care Campus; Israel Defense Forces Medical Corps; Freie Universität Berlin
- Amnon Shahar🇮🇱🇩🇪Rambam Health Care Campus; Israel Defense Forces Medical Corps; Freie Universität Berlin
- M. David Wiener🇮🇱🇩🇪Rambam Health Care Campus; Israel Defense Forces Medical Corps; Freie Universität Berlin
- Z. Joachims🇮🇱🇩🇪Rambam Health Care Campus; Israel Defense Forces Medical Corps; Freie Universität Berlin
- Abraham Netzer🇮🇱🇩🇪Rambam Health Care Campus; Israel Defense Forces Medical Corps; Freie Universität Berlin
- Hartmut Ising🇮🇱🇩🇪Rambam Health Care Campus; Israel Defense Forces Medical Corps; Freie Universität Berlin
- Ekkehard Rebentisch🇮🇱🇩🇪Rambam Health Care Campus; Israel Defense Forces Medical Corps; Freie Universität Berlin
- T Guenther🇮🇱🇩🇪Rambam Health Care Campus; Israel Defense Forces Medical Corps; Freie Universität Berlin
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Following animal experiments where correlations were observed between serum magnesium level and noise-induced permanent hearing threshold shifts (NIPTS), we tested the prophylactic effect of magnesium in human subjects exposed to hazardous noise.
Methods
Subjects were 300 young, healthy, and normal-hearing recruits who underwent 2 months of basic military training. This training necessarily included repeated exposures to high levels of impulse noises while using ear plugs. During this placebo-controlled, double-blind study, each subject received daily an additional drink containing either 6.7 mmol (167 mg) magnesium aspartate or a similar quantity of placebo (Na-aspartate).
Results
NIPTS was significantly more frequent and more severe in the placebo group than in the magnesium group, especially in bilateral damages. NIPTS was negatively correlated to the magnesium content of blood red cells but especially to the magnesium mononuclear cells. Long-term additional intake of a small dose of oral magnesium was not accompanied by any notable side effect.
Conclusion
This study may introduce a significant natural agent for the reduction of hearing damages in noise-exposed population.
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