Different effects of eicosapentaenoic acid and olive oil on blood pressure, intracellular free platelet calcium, and plasma lipids in patients with essential hypertension
Passfall J, Philipp T, Woermann F, Quass P, Thiede M, Haller H
The Clinical investigator · 15 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1993-08-01 · Clin Investig · vol. 71 · número 8 · págs. 628–33
- Editorial
- Springer Science+Business Media
- Citado
- 23 citas · más que el 77% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Blood Pressure and Hypertension Studies · Eicosanoids and Hypertension Pharmacology
- Palabras clave
- eicosapentaenoic acid, fish oil supplementation, olive oil, essential hypertension, blood pressure, plasma triglycerides, serum lipoproteins, renin activity, norepinephrine, epinephrine, dietary fat
- MeSH
- blood platelets, humans, hypertension, calcium, lipids, dietary fats, unsaturated, eicosapentaenoic acid, plant oils, double-blind method, blood pressure, adult, middle aged, female, male, olive oil
6 autores
- J. Paßfall🇩🇪Freie Universität Berlin
- T Philipp🇩🇪Freie Universität Berlin
- F. Woermann🇩🇪Freie Universität Berlin
- Petra Quass🇩🇪Freie Universität Berlin
- Hans Michael Thiede🇩🇪Freie Universität Berlin
- Hermann G. Haller🇩🇪Freie Universität Berlin
Resumen
El texto original del estudio, en el idioma en que se publicó.
In a randomized, double-blind, crossover study our specific aim was to examine the effects of a dietary fish oil or olive oil supplementation on blood pressure, intracellular free platelet calcium, plasma lipoproteins, and circulating vasoactive substances such as norepinephrine, epinephrine, and renin in patients with essential hypertension. Ten hypertensive patients (WHO classes I, II) were randomly assigned to receive 9 g fish oil or 9 g olive oil daily for 6 weeks after a 4-week baseline period. The 6-week treatment periods were separated by a 4-week wash-out. During treatment with fish oil diastolic blood pressure decreased from 103 +/- 1 to 98 +/- 2 mmHg (P < 0.05) but did not change significantly during olive oil intake. Systolic blood pressure was not affected by either treatment. Intracellular free platelet calcium decreased in patients receiving fish oil (from 102 +/- 8 nM to 86 +/- 6 nM, P < 0.05) but was not significantly altered by olive oil treatment. In contrast, the dose-response curve for thrombin-induced intracellular free platelet calcium was not altered by the fish oil enriched diet. Plasma triglycerides decreased by approximately 40% in the fish oil group while low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and total cholesterol were not altered. Renin activity, norepinephrine, and epinephrine in plasma were not influenced by fish oil supplementation. We conclude that a moderate increase in dietary fish oil reduces diastolic blood pressure, intracellular free platelet calcium, and plasma triglycerides in patients with essential hypertension.(ABSTRACT TRUNCATED AT 250 WORDS)
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