Effects of long-term oral magnesium chloride replacement in congestive heart failure secondary to coronary artery disease
Bashir Y, Sneddon JF, Staunton HA, Haywood GA, Simpson IA, McKenna WJ, Camm AJ
The American journal of cardiology · 44 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1993-11-01 · Am J Cardiol · vol. 72 · número 15 · págs. 1156–1162
- Editorial
- Elsevier BV
- Citado
- 70 citas · más que el 82% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Heart Failure Treatment and Management · Cardiac electrophysiology and arrhythmias
- Palabras clave
- magnesium chloride, magnesium supplementation, congestive heart failure, coronary artery disease, hypomagnesemia, ventricular arrhythmias, premature ventricular contractions, non-sustained ventricular tachycardia, serum magnesium, serum potassium, urinary magnesium excretion, plasma epinephrine, systemic vascular resistance, mean arterial pressure, sudden death
- MeSH
- humans, tachycardia, ventricular, coronary disease, magnesium chloride, electrolytes, administration, oral, analysis of variance, double-blind method, time factors, adult, aged, middle aged, female, male, heart failure, hemodynamics
7 autores
- Yaver Bashir🇬🇧 · autor de correspondenciaSt George's, University of London
- James F. Sneddon🇬🇧St George's, University of London
- H.Anne Staunton🇬🇧St George's, University of London
- Guy A. Haywood🇬🇧St George's, University of London
- Iain A. Simpson🇬🇧St George's, University of London
- William John McKenna🇬🇧St George's, University of London
- A. John Camm🇬🇧St George's, University of London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Magnesium deficiency frequently develops in patients with congestive heart failure and may increase susceptibility to lethal arrhythmias and sudden death via multiple pathophysiologic mechanisms. The effects of peroral magnesium supplementation were investigated in a randomized, double-blind, crossover trial involving 21 patients with stable congestive heart failure secondary to coronary artery disease. All were receiving long-term loop diuretics, and had normal renal function, and low or normal serum magnesium concentrations. Subjects alternately received enteric-coated magnesium chloride (15.8 mmol magnesium per day) and placebo for 6 weeks. Magnesium therapy increased serum magnesium from 0.87 +/- 0.07 to 0.92 +/- 0.05 mmol/liter (p < 0.05), serum potassium from 4.0 +/- 0.3 to 4.3 +/- 0.4 mmol/liter (p < 0.01) and urinary magnesium excretion from 2.82 +/- 0.96 to 4.74 +/- 2.38 mmol/24 hours (p = 0.001). There was no significant change in heart rate or Doppler cardiac index, but mean arterial pressure decreased from 91 +/- 10 to 87 +/- 10 mm Hg (p < 0.05) and systemic vascular resistance from 1,698 +/- 367 to 1,613 +/- 331 dynes s cm-5 (p = 0.047). The frequency of isolated ventricular premature complexes was reduced by 23% (95% confidence interval [CI] 6 to 37%; p < 0.02), couplets by 52% (95% CI 30 to 65%; p < 0.001) and nonsustained ventricular tachycardia episodes by 24% (95% CI 15 to 49%; p < 0.01). Plasma epinephrine decreased from 447 +/- 535 to 184 +/- 106 pg/ml (p = 0.02), but there was no corresponding change in plasma norepinephrine or heart rate variability.(ABSTRACT TRUNCATED AT 250 WORDS)
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