Does fish oil lower blood pressure? A meta-analysis of controlled trials
Morris MC, Sacks F, Rosner B
Circulation · 398 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- NIEHS NIH HHS
- Subvenciones
- National Institute of Environmental Health Sciences (5T32 ES 07069)
Según 2 financiadores declarados.
Publicación
- Publicado
- 1993-08-01 · Circulation · vol. 88 · número 2 · págs. 523–533
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 686 citas · más que el 88% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 62 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Blood Pressure and Hypertension Studies · Eicosanoids and Hypertension Pharmacology
- Palabras clave
- fish oil, omega-3 fatty acids, blood pressure, eicosapentaenoic acid, docosahexaenoic acid, dose-response relationship, hypertension, hypercholesterolemia, atherosclerotic cardiovascular disease, antihypertensive effect
- MeSH
- humans, fatty acids, omega-3, fish oils, placebos, blood pressure, research design, adult, aged, middle aged, female, male, randomized controlled trials as topic
3 autores
- Martha Clare Morris🇺🇸Harvard University
- Frank M. Sacks🇺🇸Harvard University
- BERNARD A. ROSNER🇺🇸Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
In a meta-analysis of 31 placebo-controlled trials on 1356 subjects, we examined the effect of omega-3 fatty acids in fish oil on blood pressure by grouping studies that were similar in fish oil dose, length of treatment, health of the subjects, or study design.
Methods and results
The mean reduction in blood pressure caused by fish oil for the 31 studies was -3.0/-1.5 mm Hg (95% confidence intervals: systolic blood pressure: -4.5, -1.5; diastolic blood pressure: -2.2, -0.8). There was a statistically significant dose-response effect when studies were grouped by omega-3 fatty acid dose: -1.3/-0.7 mm Hg at doses < or = 3 g/d, -2.9/-1.6 mm Hg at 3.3 to 7 g/d, and -8.1/-5.8 mm Hg at 15 g/d. Both eicosapentaenoic acid and docosahexaenoic acid were significantly related to blood pressure response. There was no effect on blood pressure in eight studies of "healthy" persons (mean reduction, -0.4/-0.7 mm Hg) at an overall mean dose of 4.2 g omega-3 fatty acids/d. By contrast, there was a significant effect of -3.4/-2.0 mm Hg in the group of hypertensive studies with a mean fish oil dose of 5.6 g/d and on systolic blood pressure only in six studies of hypercholesterolemic patients (-4.4/-1.1 mm Hg) with a mean dose of 4.0 g/d. A nonsignificant decrease in blood pressure was observed in four studies of patients with atherosclerotic cardiovascular disease (-6.3/-2.9 mm Hg). Variations in the length of treatment (from 3 to 24 weeks), type of placebo, and study design (crossover or parallel groups) did not appear to account for inconsistent findings among studies.
Conclusions
There is a dose-response effect of fish oil on blood pressure of -0.66/-0.35 mm Hg/g omega-3 fatty acids. The hypotensive effect may be strongest in hypertensive subjects and those with clinical atherosclerotic disease or hypercholesterolemia.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.