Caffeine self-administration and withdrawal: incidence, individual differences and interrelationships
Hughes JR, Oliveto AH, Bickel WK, Higgins ST, Badger GJ
Drug and alcohol dependence · 41 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Drug Abuse
- Gobierno
- NIDA NIH HHS
- Subvenciones
- National Institute on Drug Abuse (DA-04843); National Institute on Drug Abuse (DA00109); National Institute on Drug Abuse (DA07242)
Según 2 financiadores declarados.
Publicación
- Publicado
- 1993-05-01 · Drug Alcohol Depend · vol. 32 · número 3 · págs. 239–246
- Editorial
- Elsevier BV
- Citado
- 85 citas · más que el 83% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 37 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Substance Abuse Treatment and Outcomes · Neurotransmitter Receptor Influence on Behavior
- Palabras clave
- caffeine withdrawal, caffeinated coffee, sleepiness, individual differences, caffeine consumption
- MeSH
- humans, substance-related disorders, substance withdrawal syndrome, caffeine, neurologic examination, self administration, prospective studies, double-blind method, individuality, arousal, dose-response relationship, drug, coffee, adult, middle aged, female, male
5 autores
- John R. Hughes🇺🇸 · autor de correspondenciaUniversity of Vermont
- Alison H. Oliveto🇺🇸University of Vermont
- Warren Kurt Bickel🇺🇸University of Vermont
- Stephen T. Higgins🇺🇸University of Vermont
- Gary J. Badger🇺🇸University of Vermont
Resumen
El texto original del estudio, en el idioma en que se publicó.
In four prior studies, caffeine (100 mg) self-administration was assessed by greater self-administration of caffeinated coffee than decaffeinated coffee and caffeine withdrawal was assessed by placebo substitution using six double-blind tests in each subject. This paper collates data across these studies to examine the incidence and predictors of the occurrence of caffeine self-administration and withdrawal. Caffeine self-administration occurred in 31% of subjects when a consistency criterion was used (n = 41) and 27% when a statistical criterion was used. Caffeine withdrawal occurred in 35% and 49% of subjects with each criteria (n = 37). Subjects who had withdrawal headaches and drowsiness were 2.3-2.6 times more likely to self-administer the caffeinated coffee. Several variables (e.g., average caffeine intake) did not predict caffeine self-administration or withdrawal.
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