Effect of dietary fish oil on renal function and rejection in cyclosporine-treated recipients of renal transplants
van der Heide JJ, Bilo HJ, Donker JM, Wilmink JM, Tegzess AM
The New England journal of medicine · 121 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1993-09-09 · N Engl J Med · vol. 329 · número 11 · págs. 769–773
- Editorial
- Massachusetts Medical Society
- Citado
- 195 citas · más que el 100% de estudios similares · 15.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Renal Transplantation Outcomes and Treatments · Fatty Acid Research and Health · Transplantation: Methods and Outcomes
- Palabras clave
- dietary fish oil, kidney transplantation, cyclosporine, acute rejection, renal hemodynamics, glomerular filtration rate, effective renal plasma flow, blood pressure, graft survival, coconut oil, immunosuppression, omega-3 fatty acids
- MeSH
- kidney, humans, cyclosporine, fish oils, plant oils, adjuvants, immunologic, glomerular filtration rate, kidney transplantation, double-blind method, graft rejection, graft survival, renal circulation, adolescent, adult, aged, middle aged, child, child, preschool, hemodynamics, coconut oil, immunosuppression therapy
5 autores
- Jaap J. Homan van der Heide🇳🇱University Medical Center Groningen
- H. J. G. Bilo
- J.M. Ab Donker
- J. M. Wilmink🇳🇱Amsterdam UMC Location University of Amsterdam
- ADAM M. TEGZESS🇳🇱University Medical Center Groningen
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Dietary fish oil exerts effects on renal hemodynamics and the immune response that may benefit renal-transplant recipients treated with cyclosporine. To evaluate this possibility, we studied the effect of fish oil on renal function, blood pressure, and the incidence of acute rejection episodes in cyclosporine-treated recipients of renal transplants.
Methods
In a randomized, double-blind trial, 33 recipients of first cadaveric kidney transplants who were treated with cyclosporine and prednisolone ingested 6 g of fish oil daily during the first postoperative year (the fish-oil group), whereas another 33 renal-graft recipients treated with cyclosporine and prednisolone ingested 6 g of coconut oil daily for three months after which time it was stopped (the control group).
Results
One year after transplantation, the fish-oil group had higher median values than the controls for glomerular filtration rate (53 vs. 40 ml per minute per 1.73 m2, P = 0.038) and effective renal plasma flow (214 vs. 178 ml per minute per 1.73 m2, P = 0.023) and lower mean arterial pressure (103 vs. 118 mm Hg, P = 0.0011). The cyclosporine doses in the two groups were similar. The cumulative number of rejection episodes was 20 in the controls, as compared with 8 in the fish-oil group (P = 0.029). One-year graft survival also tended to be better in the fish-oil group, (97 vs. 84 percent, P = 0.097).
Conclusions
The daily administration of 6 g of fish oil during the first postoperative year has a beneficial effect on renal hemodynamics and blood pressure in renal-transplant recipients treated with cyclosporine. Although the fish-oil group had significantly fewer rejection episodes than the control group, graft survival at one year was not significantly better in the fish-oil group.
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