Influence of oral magnesium supplementation on cardiac events among survivors of an acute myocardial infarction
Galløe AM, Rasmussen HS, Jørgensen LN, Aurup P, Balsløv S, Cintin C, Graudal N, McNair P
BMJ (Clinical research ed.) · 9 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1993-09-04 · BMJ · vol. 307 · número 6904 · págs. 585–587
- Citado
- 36 citas · más que el 77% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 25 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Acute Myocardial Infarction Research · Cardiac Health and Mental Health
- Palabras clave
- oral magnesium supplementation, magnesium hydroxide, acute myocardial infarction, myocardial infarction survivors, secondary prevention, cardiac events, reinfarction, sudden death, coronary artery bypass grafting, long-term treatment safety
- MeSH
- humans, death, sudden, cardiac, myocardial infarction, recurrence, magnesium hydroxide, long-term care, coronary artery bypass, administration, oral, risk factors, double-blind method, adult, aged, aged, 80 and over, middle aged, female, male
8 autores
- Anders Michael Galloe🇩🇰Bispebjerg Hospital
- Henrik Sandvad Rasmussen🇩🇰Bispebjerg Hospital
- Lars Nannestad Jørgensen🇩🇰Bispebjerg Hospital; Hvidovre Hospital
- Peter Aurup🇩🇰Bispebjerg Hospital
- S. Balsløv🇩🇰Bispebjerg Hospital
- Christina Cintin🇩🇰Bispebjerg Hospital
- Niels Albert Graudal🇩🇰Bispebjerg Hospital
- Peter McNair🇩🇰Bispebjerg Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To investigate the effect of long term oral magnesium treatment on incidence of cardiac events among survivors of an acute myocardial infarction.
Design
Double blind, placebo controlled parallel study in which patients were randomised to treatment or placebo.
Setting
Two coronary care units and corresponding outpatient clinics.
Subjects
468 survivors of an acute myocardial infarction (289 men and 178 women) aged 31-92.
Interventions
One tablet of 15 mmol magnesium hydroxide or placebo daily for one year.
Main outcome measures
Incidences of reinfarction, sudden death, and coronary artery bypass grafting in one year.
Results
There was no significant difference between treatment and placebo groups in the incidence of each of the three cardiac events, but when the events were combined and drop outs were excluded from calculations there was a significantly higher incidence of events in the treatment group (56/167 v 33/153; relative risk 1.55 (95% confidence interval 1.07 to 2.25); p = 0.02). When the timing of events was incorporated by means of a Kaplan-Meier plot the treatment group showed a significantly higher incidence of events whether drop outs were included or excluded (p < 0.025).
Conclusion
Long term oral treatment with 15 mmol magnesium daily doses not reduce the incidence of cardiac events in survivors of an acute myocardial infarction and, indeed, seems to increase the risk of developing a cardiac event. Consequently, this treatment cannot be recommended as secondary prophylaxis for such patients.
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