Dietary fish oil augments nitric oxide production or release in patients with type 2 (non-insulin-dependent) diabetes mellitus
McVeigh GE, Brennan GM, Johnston GD, McDermott BJ, McGrath LT, Henry WR, Andrews JW, Hayes JR
Diabetologia · 132 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1993-01-01 · Diabetologia · vol. 36 · número 1 · págs. 33–38
- Editorial
- Springer Science+Business Media
- Citado
- 193 citas · más que el 99% de estudios similares · 9.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 30 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Nitric Oxide and Endothelin Effects · Cardiovascular Health and Disease Prevention
- Palabras clave
- fish oil, omega-3 fatty acids, nitric oxide, endothelium-dependent vasodilation, type 2 diabetes, acetylcholine, nitroglycerin, forearm blood flow, olive oil, endothelial dysfunction, vasospasm, thrombosis
- MeSH
- forearm, blood platelets, cell membrane, humans, diabetes mellitus, type 2, nitric oxide, acetylcholine, cholesterol, blood glucose, dietary fats, docosahexaenoic acids, eicosapentaenoic acid, arachidonic acid, triglycerides, membrane lipids, fish oils, plant oils, arginine, omega-n-methylarginine, double-blind method, blood pressure, heart rate, vascular resistance, middle aged, female, male, hemodynamics, olive oil, glycated hemoglobin
8 autores
- Gary Eugene McVeigh🇬🇧Queen's University Belfast
- G. Brennan🇬🇧Queen's University Belfast
- G. D. Johnston🇬🇧Queen's University Belfast
- B. J. McDermott🇬🇧Queen's University Belfast
- Lawrence T. McGrath🇬🇧Queen's University Belfast
- W. R. Henry🇬🇧Belfast City Hospital
- J. W. Andrews
- J. R. Hayes🇬🇧Belfast City Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Decreased release of nitric oxide from damaged endothelium is responsible for the impaired endothelium-dependent vasodilator responses found in animal models of vascular disease. Dietary supplementation with fish oils has been shown to augment endothelium-dependent relaxations, principally by improving the release of nitric oxide from injured endothelium. Using forearm venous occlusion plethysmography we studied vascular responses to 60, 120, 180 and 240 nmol/min of acetylcholine (an endothelium-dependent vasodilator) and 3, 6 and 9 nmol/min of glyceryl trinitrate (an endothelium-independent vasodilator) infused into the brachial artery in 23 patients with Type 2 (non-insulin-dependent) diabetes mellitus. NG monomethyl-L-arginine was employed to inhibit stimulated and basal release of nitric oxide from the endothelium. On completion of the baseline studies patients randomly received either fish oil or matching olive oil capsules in a double-blind crossover fashion for 6 weeks followed by a 6-week washout period and a final 6-week treatment phase. Studies, identical to the initial baseline studies, were performed at the end of the active treatment periods at 6 and 18 weeks. Fish oil supplementation significantly improved forearm blood flow responses to each dose of acetylcholine when compared to the vasodilator responses recorded at baseline and after olive oil administration (p < 0.01). Neither fish oil nor olive oil supplementation produced any significant changes in forearm blood flow to the incremental infusions of glyceryl trinitrate when compared with responses recorded during the baseline studies.(ABSTRACT TRUNCATED AT 250 WORDS)
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