Financiado en parte por Nestec
The role of fatty acid saturation on plasma lipids, lipoproteins, and apolipoproteins: I. Effects of whole food diets high in cocoa butter, olive oil, soybean oil, dairy butter, and milk chocolate on the plasma lipids of young men
Kris-Etherton PM, Derr J, Mitchell DC, Mustad VA, Russell ME, McDonnell ET, Salabsky D, Pearson TA
Metabolism: clinical and experimental · 100 citas
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Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Organización sin fines de lucro
- American Research Institute in Turkey
- Universidad u hospital
- Johns Hopkins University
- Empresa
- Nestec
Según 3 financiadores declarados.
Publicación
- Publicado
- 1993-01-01 · Metabolism · vol. 42 · número 1 · págs. 121–129
- Editorial
- Elsevier BV
- Citado
- 169 citas · más que el 100% de estudios similares · 16.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 29 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Fatty Acid Research and Health · Cholesterol and Lipid Metabolism · Lipoproteins and Cardiovascular Health
- Palabras clave
- fatty acid saturation, stearic acid, cocoa butter, olive oil, soybean oil, milk chocolate, myristic acid, lauric acid, oleic acid, linoleic acid, dietary fat, serum cholesterol, LDL cholesterol, apolipoprotein B, apolipoprotein A-I, hypercholesterolemia, hypocholesterolemia
- MeSH
- humans, cacao, lipids, dietary fats, butter, soybean oil, fatty acids, lipoproteins, plant oils, apolipoproteins, double-blind method, adult, male, olive oil
8 autores
- Penny M. Kris‐Etherton🇺🇸 · autor de correspondenciaPennsylvania State University; Columbia University
- Janice Derr🇺🇸Pennsylvania State University; Columbia University
- Diane C. Mitchell🇺🇸Pennsylvania State University; Columbia University
- Vikkie A. Mustad🇺🇸Pennsylvania State University; Columbia University
- Mary E. Russell🇺🇸Pennsylvania State University; Columbia University
- Elaine T. McDonnell🇺🇸Pennsylvania State University; Columbia University
- Deborah Salabsky🇺🇸Pennsylvania State University; Columbia University
- Thomas A. Pearson🇺🇸Pennsylvania State University; Columbia University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The present studies were conducted to evaluate the cholesterolemic effects of whole-food diets high in stearic acid. In study no. 1, normocholesterolemic young men were fed diets high in stearic acid provided by cocoa butter (CB); oleic acid provided by olive oil (OO); linoleic acid provided by soybean oil (SO); and myristic acid (and lauric acid) provided by dairy butter (B). In study no. 2, different subjects with similar baseline characteristics were fed diets high in stearic acid provided by milk chocolate (C), CB, CB+B (4:1, MIX), and myristic (and lauric) acid provided by B. Both studies used a randomized, crossover, double-blind experimental design, and experimental subjects (n = 18 for study no. 1 and n = 15 for study no. 2) in each study consumed every diet for 26 days with a 1-month wash-out period between each experimental period. The diets provided 37% of calories from fat, of which 81% was provided by the test fat. Ten ounces (280 g) C was provided daily by the C diet. In study no. 1, the B diet was hypercholesterolemic, whereas the SO diet was hypocholesterolemic, compared with the other diets. The OO and SO diets were hypocholesterolemic compared with the CB diet. Low-density lipoprotein (LDL) cholesterol levels, in general, paralleled the changes in plasma total cholesterol levels. SO significantly decreased apolipoprotein (apo) B levels compared with the other diets. Plasma very-low density lipoprotein (VLDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and apo A-I levels were unaffected by the experimental diets.(ABSTRACT TRUNCATED AT 250 WORDS)
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