Oral magnesium supplementation as prophylaxis for noise-induced hearing loss: results of a double blind field study
Joachims Z, Netzer A, Ising H, Rebentisch E, Attias J, Weisz G, Günther T
Schriftenreihe des Vereins fur Wasser-, Boden- und Lufthygiene · 18 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1993-01-01 · Schriftenr Ver Wasser Boden Lufthyg · vol. 88 · págs. 503–16
- Editorial
- National Institutes of Health
- Citado
- 31 citas · más que el 0% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Hearing, Cochlea, Tinnitus, Genetics · Noise Effects and Management · Magnesium in Health and Disease
- Palabras clave
- magnesium supplementation, noise-induced hearing loss, hearing loss prevention, gunshot noise, military recruits, permanent threshold shift, serum magnesium, erythrocyte magnesium, earplugs, audiometry
- MeSH
- humans, hearing loss, noise-induced, occupational diseases, magnesium, administration, oral, double-blind method, ear protective devices, auditory threshold, noise, occupational, adolescent, military personnel, israel, male
7 autores
- Z. Joachims
- Abraham Netzer
- Hartmut Ising
- Ekkehard Rebentisch
- Joseph Attias
- Giora Weisz
- Thomas Günther
Resumen
El texto original del estudio, en el idioma en que se publicó.
The effect of oral Mg-supplementation as prophylaxis against noise-induced hearing loss was tested in a placebo-controlled double blind study involving 320 voluntary subjects during a 2-month period of military training. The hearing thresholds of all subjects were checked and only persons with normal hearing were accepted. Before and after the 2-month training, blood samples were collected and Mg was analysed in serum, erythrocytes and lymphocytes. Seven days after the last exposure to firearm noise, the audiograms of all test subjects were checked and permanent threshold shifts (PTS) were determined. The total group received a drink containing either 4g Mg granulate verum (6.7 mmol Mg aspartate) or placebo every working day during the 2-month training period. The primary source of noise exposure were firearms: 420 shots per person, mean peak level 164 dB(A). The recruits used ear plugs with a mean insertion loss of 25 dB. In both groups Mg-concentration in serum and in erythrocytes increased with time. Lymphocyte Mg increased in the Mg group only. In the placebo group the percentages of ears with PTS > 25 dB at 4 kHz/6 kHz and/or 8 kHz after exposure to firearm noise were twice as high as in the Mg group.
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