Declining cholesterol and mortality in a sample of older nursing home residents
Grant MD, Piotrowski ZH, Miles TP
Journal of the American Geriatrics Society · 17 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1996-01-01 · J Am Geriatr Soc · vol. 44 · número 1 · págs. 31–36
- Editorial
- Wiley
- Citado
- 29 citas · más que el 95% de estudios similares · 5.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 30 trabajos
- Acceso
- De pago
- Áreas de investigación
- Geriatric Care and Nursing Homes · Lipoproteins and Cardiovascular Health · Nutrition and Health in Aging
- Palabras clave
- serum cholesterol, mortality, nursing home residents, older adults, mortality prediction, tube feeding
- MeSH
- humans, weight loss, cholesterol, enteral nutrition, cause of death, odds ratio, regression analysis, survival analysis, retrospective studies, cohort studies, aged, aged, 80 and over, homes for the aged, nursing homes, female, male, biomarkers
3 autores
- Mark D Grant🇺🇸 · autor de correspondenciaUniversity of Illinois Chicago; West Suburban Medical Center
- Zdzislaw H. Piotrowski🇺🇸West Suburban Medical Center
- Toni P. Miles🇺🇸Pennsylvania State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine the association between declining serum cholesterol and mortality in a sample of older nursing home residents.
Design
A retrospective cohort study.
Setting
A 203-bed nursing home.
Participants
Persons aged 65 and older, resident in the nursing home on January 1, 1988, or admitted through December 31, 1989, were eligible (n = 185) for the study. Follow-up for mortality was conducted until June 30, 1991. Fifty-five survivors with two or more cholesterol levels recorded before January 1, 1990, and the 76 decedents with two or more recorded cholesterol levels constituted the analytic sample (71% of eligible subjects).
Outcome measure
Mortality of the nursing home residents.
Results
Cholesterol declined 31.1 mg/dL/yr (95% confidence interval [CI], 19.7 to 42.6) among decedents, versus 4.2 mg/dL/yr (95% CI, -4.9 to 13.2) among survivors. The association between cholesterol decline (absolute or relative rates) and mortality was examined using logistic regression controlling for age, sex, and tube feeding. Compared with a referrent group with no change or increase, declining cholesterol greater than 45 mg/dL/yr was accompanied by an adjusted relative odds for death of 6.2 (95% CI, 2.1 to 18.4); declining cholesterol greater than 20% per year was accompanied by an adjusted relative odds for death of 7.3 (95% CI; 2.4 to 22.2). Extreme declines greater than 20% per year occurred in 47% of decedents but in only 15% of survivors.
Conclusion
Precipitously declining cholesterol appeared to be a marker for mortality in the sample and may help explain the low cholesterol-mortality association in older nursing home residents.
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