Essential fatty acid status in neonates after fish-oil supplementation during late pregnancy
van Houwelingen AC, Sørensen JD, Hornstra G, Simonis MM, Boris J, Olsen SF, Secher NJ
The British journal of nutrition · 100 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1995-11-01 · Br J Nutr · vol. 74 · número 5 · págs. 723–731
- Editorial
- Cambridge University Press
- Citado
- 160 citas · más que el 94% de estudios similares · 4.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 30 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Birth, Development, and Health · Lipid metabolism and biosynthesis
- Palabras clave
- fish oil supplementation, omega-3 fatty acids, late pregnancy, maternal nutrition, umbilical cord blood, docosahexaenoic acid, Mead acid, omega-6 fatty acids, neonatal neurodevelopment, olive oil
- MeSH
- umbilical arteries, umbilical veins, fetal blood, humans, fatty acids, omega-3, docosahexaenoic acids, phospholipids, nutritional status, pregnancy, maternal-fetal exchange, pregnancy trimester, third, adult, infant, newborn, female
7 autores
- Adriana C van Houwelingen🇳🇱Maastricht University
- Jannie Dalby Sørensen🇩🇰Aarhus University
- Gerard Hornstra🇳🇱Maastricht University
- Marianne M. G. Simonis🇳🇱Maastricht University
- J. P. Boris🇩🇰Aarhus University
- Sjurdur Frodi Olsen🇩🇰Aarhus University
- Niels Jørgen Secher🇩🇰Aarhus University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Healthy pregnant women (n 23) were supplemented with fish-oil capsules (2.7 g n-3 polyunsaturated fatty acids/d) from the 30th week of gestation until delivery. Subjects in a control group were either supplemented with olive-oil capsules (4 g/d, n 6) or received no supplementation (n 10). Fatty acid compositions of the phospholipids isolated from umbilical plasma and umbilical arterial and venous vessel walls were determined. Fatty acid compositions of maternal venous plasma phospholipids were determined as well. Maternal plasma phospholipids of the fish-oil-supplemented group contained more n-3 fatty acids and less n-6 fatty acids. Moreover, the amounts of the essential fatty acid deficiency markers Mead acid (20:3n-9) and Osbond acid (22:5n-6) were significantly lower. The extra amount of n-3 fatty acids consumed by the mothers resulted in higher contents of n-3 fatty acids, and of docosahexaenoic acid (22:6n-3) in particular, in the phospholipids of umbilical plasma and vessel walls. It is, indeed, possible to interfere with the docosahexaenoic acid status at birth: children born to mothers supplemented with fish oil in the last trimester of pregnancy start with a better docosahexaenoic acid status at birth, which may be beneficial to neonatal neurodevelopment.
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