Fish oil supplementation inhibits the expression of major histocompatibility complex class II molecules and adhesion molecules on human monocytes
Hughes DA, Pinder AC, Piper Z, Johnson IT, Lund EK
The American journal of clinical nutrition · 118 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1996-02-01 · Am J Clin Nutr · vol. 63 · número 2 · págs. 267–272
- Editorial
- Elsevier BV
- Citado
- 191 citas · más que el 99% de estudios similares · 12.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- fish oil supplementation, omega-3 fatty acids, monocytes, MHC class II expression, HLA-DR, HLA-DP, HLA-DQ, ICAM-1, LFA-1, antigen presentation, interferon-gamma, cell-mediated immunity, dietary fatty acids
- MeSH
- monocytes, cells, cultured, humans, fatty acids, omega-3, cell adhesion molecules, antibodies, monoclonal, histocompatibility antigens class ii, fluorescent antibody technique, cell separation, patient compliance, major histocompatibility complex, up-regulation, adult, female, male, interferon-gamma
5 autores
- David A. Hughes🇬🇧Norwich Research Park; Quadram Institute
- Andrew C. Pinder🇬🇧Norwich Research Park; Quadram Institute
- Zoe Piper🇬🇧Norwich Research Park; Quadram Institute
- Ian T. Johnson🇬🇧Norwich Research Park; Quadram Institute
- Elizabeth K. Lund🇬🇧Norwich Research Park; Quadram Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
To test the hypothesis that fish oil supplementation can inhibit the expression of functionally associated molecules on the surface of human blood monocytes, we randomly assigned 12 healthy adults to receive either an n-3 polyunsaturated fatty acid-rich fish oil supplement for 21 d or to receive no supplement. The percentage of monocytes expressing major histocompatibility complex (MHC) class II molecules (HLA-DR, -DP, and -DQ), intercellular adhesion molecule-1, and leukocyte-function-associated antigen-1, and the intensity of expression of each molecule were quantified before and after the study period. Monocytes were examined immediately after blood sampling and again after incubation in serum-free culture medium for 24 h in the presence of interferon-gamma to up-regulate expression of MHC class II molecules by the monocytes. The intensity of expression of all the monocyte surface molecules examined was significantly reduced after fish oil supplementation (P < 0.025), although there was no change in the percentage of monocytes expressing each molecule. After incubation with interferon-gamma, there was a similar inhibition of surface molecule expression (with the exception of HLA-DQ) by monocytes from the fish oil-supplemented group, and there was a reduction in the percentage of monocytes expressing both HLA-DR and -DP molecules (P < 0.025). No significant changes were observed in the reference group. Dietary supplementation with fish oil can inhibit the expression of surface molecules involved in the function of human antigen-presenting cells, a potential mechanism by which n-3 fatty acids may suppress cell-mediated immune responses.
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