Effect of linoleic acid intake on growth of infants with cystic fibrosis
van Egmond AW, Kosorok MR, Koscik R, Laxova A, Farrell PM
The American journal of clinical nutrition · 56 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-34108); National Center for Research Resources (RR03186)
Según 4 financiadores declarados.
Publicación
- Publicado
- 1996-05-01 · Am J Clin Nutr · vol. 63 · número 5 · págs. 746–752
- Editorial
- Elsevier BV
- Citado
- 89 citas · más que el 95% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 46 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Infant Nutrition and Health · Fatty Acid Research and Health · Clinical Nutrition and Gastroenterology
- Palabras clave
- cystic fibrosis, linoleic acid, infant growth, essential fatty acid deficiency, malabsorption, height-for-age, weight-for-age, infant nutrition
- MeSH
- humans, cystic fibrosis, deficiency diseases, growth disorders, body weight, fatty acids, essential, linoleic acids, linoleic acid, body height, prevalence, longitudinal studies, age factors, energy intake, growth, infant food, infant, infant, newborn, wisconsin, female, male
5 autores
- AW van Egmond🇺🇸University of Wisconsin–Madison; UW Health University Hospital
- MR Kosorok🇺🇸University of Wisconsin–Madison
- Rebecca E. Koscik🇺🇸University of Wisconsin–Madison; UW Health University Hospital
- Anita Laxova🇺🇸University of Wisconsin–Madison; UW Health University Hospital
- PM Farrell🇺🇸University of Wisconsin–Madison; UW Health University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Essential fatty acid deficiency as a result of inadequate linoleic acid impairs growth in healthy infants and is common in infants with malabsorption due to cystic fibrosis (CF). We investigated the effect of dietary linoleic acid intake on the growth of infants with CF. In this study, predigested formula preparations A and B, with linoleic acid contents of 12% and 7% of energy, respectively, were fed before and after 1989 to infants enrolled in the evaluation and treatment protocol of the Wisconsin CF Neonatal Screening Project. Outcome was assessed from height-for-age (HAZ) and weight-for-age (WAZ) Z scores on follow-up exams during the first year. Baseline characteristics did not differ significantly between groups A (n = 43) and B (n = 33). At diagnosis, 53% of the enrolled infants (n = 76) showed low plasma linoleic acid concentrations and 22% had a high ratio of triene to tetraene. After correcting for the effect of potentially confounding variables, we found that HAZ (by .27, P < 0.05) and WAZ (by 0.26, P = 0.081) were higher in group A than in group B. This occurred despite a significantly higher energy intake in group B. This difference was most pronounced between 6 and 9 mo of age. Our results suggest that a high linoleic acid content in formula benefits infants with CF because it optimizes nutrition, growth, and feeding efficiency.
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