Alpha-linolenic acid in rapeseed oil partly compensates for the effect of fish restriction on plasma long chain n-3 fatty acids
Valsta LM, Salminen I, Aro A, Mutanen M
European journal of clinical nutrition · 41 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1996-04-01 · Eur J Clin Nutr · vol. 50 · número 4 · págs. 229–35
- Editorial
- National Institutes of Health
- Citado
- 59 citas · más que el 81% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- alpha-linolenic acid, rapeseed oil, n-3 long-chain polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid, docosapentaenoic acid, plasma phospholipids, plasma triglycerides, cholesterol esters, n-6/n-3 ratio, dietary fatty acid composition
- MeSH
- humans, helianthus, brassica, cholesterol esters, dietary fats, unsaturated, fatty acids, omega-3, alpha-linolenic acid, docosahexaenoic acids, eicosapentaenoic acid, fatty acids, fatty acids, unsaturated, fatty acids, monounsaturated, triglycerides, phospholipids, plant oils, cross-over studies, fish products, adult, middle aged, female, male, sunflower oil
4 autores
- Valsta Lm
- Irma Salminen
- Arja R. Aro
- Marja L. Mutanen
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine the ability of alpha-linolenic acid (ALA) in low erucic acid rapeseed oil (RO) to compensate for the effects of a restriction in fish intake on plasma fatty acid composition.
Design and subjects
Two times 6 weeks' randomized dietary intervention was used with blind crossover design in 40 healthy unconfined women and men (age 20-46y).
Interventions
Subjects were assigned to two fish restricted diets, namely RO diet and Trisun-sunflower oil (TSO) diet, with similar proportions of saturated : monounsaturated : polyunsaturated fatty acids (11.5:17.5:8.5% of total energy, En%), but differing in their ALA content (2.2 and 0.3 En%) and n-6 : n-3-ratio (3 : 1 and 23 : 1, respectively). The fatty acid compositions of plasma triglycerides (TG), cholesterol esters (CE), and phospholipids (PL) were analyzed by gas chromatography. Dietary intake was evaluated based on 3- to 7-day food records.
Results
The proportion of TG and CE ALA decreased on the TSO diet (from 1.6% to 0.9% and from 0.9% to 0.4%, respectively, P < 0.001) and increased on the RO diet (from 1.7% to 3.4% and from 0.9% to 1.3%, respectively, P < 0.001) compared to the baseline level. The proportion of eicosapentaenoic acid (EPA) in all three plasma fractions decreased on the TSO diet but not on the RO diet. The proportions of docosa-hexaenoic acid (DHA) decreased on both experimental diets and there was no difference in CE DHA between the diets. PL docosa-pentaenoic acid (DPA) and PL DHA remained at a higher level on the RO diet compared to the TSO diet (P < 0.001 and P < 0.05, respectively).
Conclusions
ALA is metabolized to EPA in humans to a significant extent. The degree to which rapeseed oil (ca 50g/day) affects the proportion of EPA resembled the effect of a weekly portion (50-100g) of fatty fish depending on the fat content of the fish.
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