Caffeine attenuates scopolamine-induced memory impairment in humans
Riedel W, Hogervorst E, Leboux R, Verhey F, van Praag H, Jolles J
Psychopharmacology · 94 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1995-11-01 · Psychopharmacology (Berl) · vol. 122 · número 2 · págs. 158–168
- Editorial
- Springer Science+Business Media
- Citado
- 152 citas · más que el 86% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Coffee research and impacts · Cholinesterase and Neurodegenerative Diseases · Cognitive Abilities and Testing
- Palabras clave
- caffeine, scopolamine, memory impairment, nicotine, cholinergic stimulation, adenosine antagonism, short-term memory, long-term memory, free recall, cognitive enhancement, reaction time, perceptual sensitivity, word learning
- MeSH
- humans, memory disorders, scopolamine, nicotine, caffeine, nicotinic agonists, muscarinic antagonists, central nervous system stimulants, pulse, cross-over studies, double-blind method, cognition, visual perception, psychomotor performance, blood pressure, coffee, chewing gum, adult, female, male
6 autores
- W. Reidel🇳🇱Maastricht University
- Eef Hogervorst🇳🇱Maastricht University
- R.L.A.M. Leboux🇳🇱Maastricht University
- Frans R.J. Verhey🇳🇱Maastricht University
- Herman M. van Praag🇳🇱Maastricht University
- Jelle Jolles🇳🇱Maastricht University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Caffeine consumption can be beneficial for cognitive functioning. Although caffeine is widely recognized as a mild CNS stimulant drug, the most important consequence of its adenosine antagonism is cholinergic stimulation, which might lead to improvement of higher cognitive functions, particularly memory. In this study, the scopolamine model of amnesia was used to test the cholinergic effects of caffeine, administered as three cups of coffee. Subjects were 16 healthy volunteers who received 250 mg caffeine and 2 mg nicotine separately, in a placebo-controlled double-blind cross-over design. Compared to placebo, nicotine attenuated the scopolamine-induced impairment of storage in short-term memory and attenuated the scopolamine-induced slowing of speed of short-term memory scanning. Nicotine also attenuated the scopolamine-induced slowing of reaction time in a response competition task. Caffeine attenuated the scopolamine-induced impairment of free recall from short- and long-term memory, quality and speed of retrieval from long-term memory in a word learning task, and other cognitive and non-cognitive measures, such as perceptual sensitivity in visual search, reading speed, and rate of finger-tapping. On the basis of these results it was concluded that caffeine possesses cholinergic cognition enhancing properties. Caffeine could be used as a control drug in studies using the scopolamine paradigm and possibly also in other experimental studies of cognitive enhancers, as the effects of a newly developed cognition enhancing drug should at least be superior to the effects of three cups of coffee.
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