The effects of a cold-water immersion stressor on the reinforcing and subjective effects of fentanyl in healthy volunteers
Zacny JP, McKay MA, Toledano AY, Marks S, Young CJ, Klock PA, Apfelbaum JL
Drug and alcohol dependence · 32 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Drug Abuse
- Gobierno
- NIDA NIH HHS
- Subvenciones
- National Institute on Drug Abuse (DA-09887)
Según 2 financiadores declarados.
Publicación
- Publicado
- 1996-10-01 · Drug Alcohol Depend · vol. 42 · número 2 · págs. 133–142
- Editorial
- Elsevier BV
- Citado
- 43 citas · más que el 48% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 75 trabajos
- Acceso
- De pago
- Áreas de investigación
- Neurotransmitter Receptor Influence on Behavior · Opioid Use Disorder Treatment · Pain Management and Opioid Use
- Palabras clave
- fentanyl, cold water immersion, stressors, drug reinforcement, subjective effects, opioid analgesics, pain, choice behavior
- MeSH
- humans, fentanyl, analgesics, opioid, double-blind method, immersion, infusion pumps, euphoria, motivation, pain threshold, arousal, adult, female, male, cold temperature
7 autores
- James P. Zacny🇺🇸 · autor de correspondenciaUniversity of Chicago
- Maura A. McKay🇺🇸University of Chicago
- Alicia Y. Toledano🇺🇸University of Chicago
- Sandy Marks🇺🇸University of Chicago
- Christopher J. Young🇺🇸University of Chicago
- P.Allan Klock🇺🇸University of Chicago
- Jeffrey L. Apfelbaum🇺🇸University of Chicago
Resumen
El texto original del estudio, en el idioma en que se publicó.
The reinforcing and subjective effects of fentanyl, an opioid analgesic, were tested in ten healthy volunteers without histories of drug abuse, as a function of the temperature of a water bath in which the volunteers' forearms were immersed. The temperatures were body-temperature (37 degrees C), moderately cold (10 degrees C), and very cold (2 degrees C). A discrete-trial choice procedure was used in which, in each session, volunteers sampled 50 micrograms of fentanyl (delivered as a bolus via an infusion pump) and saline, and then on three successive trials, chose between the two. Volunteers then had to immerse their non-dominant forearm in the water bath 5 min after a drug delivery. Fentanyl was chosen on 77% of choice occasions in the 10 degrees C and 2 degrees C water conditions, which was significantly different from chance levels, and on 60% of choice occasions in the 37 degrees C water condition, which did not differ from chance levels. Several subjective effects of fentanyl were also modulated by the temperature of the water bath. We conclude that in the context of a painful stimulus, 50 micrograms of fentanyl functions as a reinforcer in non-drug abusers.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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