Long-term effects of fish oil on insulin resistance and plasma lipoproteins in NIDDM patients with hypertriglyceridemia
Rivellese AA, Maffettone A, Iovine C, Di Marino L, Annuzzi G, Mancini M, Riccardi G
Diabetes care · 104 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
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Publicación
- Publicado
- 1996-11-01 · Diabetes Care · vol. 19 · número 11 · págs. 1207–1213
- Editorial
- American Diabetes Association
- Citado
- 167 citas · más que el 85% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Lipid metabolism and disorders · Edible Oils Quality and Analysis
- Palabras clave
- fish oil supplementation, omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, type 2 diabetes, hypertriglyceridemia, insulin resistance, insulin sensitivity, plasma triglycerides, VLDL triglycerides, free fatty acids, erythrocyte membrane phospholipids, n-3 long-chain polyunsaturated fatty acids, hyperinsulinemic-euglycemic clamp, long-term supplementation, glycemic control, serum insulin
- MeSH
- erythrocyte membrane, humans, diabetes mellitus, type 2, insulin resistance, hypertriglyceridemia, sulfonylurea compounds, cholesterol, insulin, blood glucose, fatty acids, nonesterified, triglycerides, lipoproteins, membrane lipids, phospholipids, fish oils, placebos, hypoglycemic agents, glucose clamp technique, fasting, postprandial period, middle aged, female, male, diet, diabetic
7 autores
- Angela Albarosa Rivellese🇮🇹Federico II University Hospital; University of Naples Federico II
- Ada Maffettone🇮🇹Federico II University Hospital; University of Naples Federico II
- Ciro Iovine🇮🇹Federico II University Hospital; University of Naples Federico II
- Lucrezia Di Marino🇮🇹Federico II University Hospital; University of Naples Federico II
- Giovanni Annuzzi🇮🇹Federico II University Hospital; University of Naples Federico II
- Mario Mancini🇮🇹Federico II University Hospital; University of Naples Federico II
- Gabriele Riccardi🇮🇹Federico II University Hospital; University of Naples Federico II
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The aim of this study was to evaluate the long-term (6-month) effects of moderate fish oil supplementation on insulin sensitivity and plasma lipoproteins in NIDDM patients with hypertriglyceridemia.
Research design and methods
The study has been performed according to a randomized double-blind placebo-controlled design with a parallel group sequence. After a washout period of 4 weeks and a run-in period of 3 weeks, 16 NIDDM patients with hypertriglyceridemia (triglyceride [TG], 2.25-5.65 mmol/l) were randomly assigned to either fish oil (2.7 g/day eicosapentaenoic plus docosahexaenoic acid for 2 months, then 1.7 g/day for 4 more months) (n = 8) or placebo (n = 8). Diet and hypoglycemic drugs remained unchanged throughout the whole experiment. At baseline and after 6 months, insulin sensitivity was measured by euglycemic hyperinsulinemic clamp (insulin infused, 2.0 mIU.kg-1 body wt.min-1). At the same time, blood glucose control, fasting and postprandial serum insulin and nonesterified fatty acid (NEFA) concentrations, and fasting plasma lipoprotein concentrations were evaluated.
Results
In the group treated with fish oil compared with the baseline, there was: 1) a significant reduction in both plasma TG (2.92 +/- 0.23 vs. 3.85 +/- 0.32 [mean +/- SE] mmol/l, P < 0.001) and VLDL-TG (2.35 +/- 0.24 vs. 4.25 +/- 0.66 mmol/l, P < 0.01), without significant changes in blood glucose control; 2) a significant reduction in fasting NEFA concentrations (572 +/- 100 vs. 825 +/- 131 mumol/l, P < 0.01); and 3) a significant enrichment in long-chain omega-3 fatty acids of erythrocyte membrane phospholipids. In the placebo group, there were no changes in any of the variables analyzed. The insulin-mediated glucose uptake was unchanged in both groups (fish oil, 4.04 +/- 0.82 mg.kg-1.min-1 at baseline and 3.96 +/- 0.50 mg.kg-1.min-1 at 6 months; placebo, 3.51 +/- 0.62 mg.kg-1.min-1 at baseline and 4.09 +/- 0.49 mg.kg-1.min-1 at 6 months).
Conclusions
In NIDDM patients with hypertriglyceridemia, moderate amounts of fish oil induce a long-term significant reduction in plasma triglycerides, VLDL triglycerides, and NEFA and a significant enrichment in the erythrocyte phospholipid content of long-chain omega-3 fatty acids, without deteriorating blood glucose control. However, this amount of omega-3 fatty acids was unable to improve insulin sensitivity in this group of patients.
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