Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans
Cater NB, Heller HJ, Denke MA
The American journal of clinical nutrition · 84 citas
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Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- U.S. Public Health Service
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Gobierno
- PHS HHS
- Subvenciones
- U.S. Public Health Service (5 T32 OK07307); National Heart, Lung, and Blood Institute (R37HL29252-15); National Heart, Lung, and Blood Institute (5-K08HL02456)
Según 4 financiadores declarados.
Publicación
- Publicado
- 1997-01-01 · Am J Clin Nutr · vol. 65 · número 1 · págs. 41–45
- Editorial
- Elsevier BV
- Citado
- 146 citas · más que el 98% de estudios similares · 8.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 21 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Coconut Research and Applications · Diet and metabolism studies
- Palabras clave
- medium-chain triglycerides, palm oil, high oleic sunflower oil, hypercholesterolemia, total cholesterol, LDL cholesterol, HDL cholesterol, plasma triglycerides, saturated fatty acids, palmitic acid, dietary fatty acid supplementation, lipid metabolism
- MeSH
- humans, hypercholesterolemia, cholesterol, lipids, fatty acids, oleic acids, triglycerides, lipoproteins, plant oils, cross-over studies, aged, middle aged, male, cholesterol, ldl, cholesterol, hdl, palm oil, sunflower oil
3 autores
- NB Cater🇺🇸 · autor de correspondenciaThe University of Texas Southwestern Medical Center
- HJ Heller🇺🇸The University of Texas Southwestern Medical Center
- MA Denke🇺🇸The University of Texas Southwestern Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Although medium-chain triacylglycerols (MCTs, composed of medium-chain fatty acids 8:0 and 10:0) have long been described as having neutral effects on serum cholesterol concentrations, experimental evidence supporting this claim is limited. In a randomized, crossover, metabolic-ward study, we compared the lipid effects of a natural food diet supplemented with either MCTs, palm oil, or high oleic acid sunflower oil in nine middle-aged men with mild hypercholesterolemia. Rather than having a neutral effect, MCT oil produced total cholesterol concentrations that were not significantly different from those produced by palm oil (MCT oil: 5.87 +/- 0.75 mmol/L; palm oil: 5.79 +/- 0.72 mmol/L) but significantly higher than that produced by high oleic acid sunflower oil (5.22 +/- 0.52 mmol/L). Low-density-lipoprotein (LDL)-cholesterol concentrations paralleled those of total cholesterol. MCT oil tended to result in higher triacylglycerol concentrations than either palm oil or high oleic acid sunflower oil, but this difference was not significant. There were no differences in high-density-lipoprotein cholesterol concentrations. The palmitic acid and total saturated fatty acid content of plasma triacylglycerols in the MCT-oil diet was not significantly different from that in the palm oil diet. On the basis of percentage of energy, this study suggests that medium-chain fatty acids have one-half the potency that palmitic acid has at raising total and LDL-cholesterol concentrations.
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