Intermediates in endogenous synthesis of C22:6 omega 3 and C20:4 omega 6 by term and preterm infants
Sauerwald TU, Hachey DL, Jensen CL, Chen H, Anderson RE, Heird WC
Pediatric research · 95 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Eye Institute
- Gobierno
- NEI NIH HHS
- Subvenciones
- National Eye Institute (EY04149); National Eye Institute (EY 00871)
Según 2 financiadores declarados.
Publicación
- Publicado
- 1997-02-01 · Pediatr Res · vol. 41 · número 2 · págs. 183–187
- Editorial
- Springer Nature
- Citado
- 149 citas · más que el 99% de estudios similares · 10.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 20 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Lipid metabolism and biosynthesis · Aquaculture Nutrition and Growth
- Palabras clave
- preterm infants, term infants, isotopic labeling, plasma phospholipids, fatty acid elongation, fatty acid desaturation, fatty acid beta-oxidation
- MeSH
- humans, docosahexaenoic acids, fatty acids, arachidonic acid, phospholipids, gestational age, infant, newborn, infant, premature
6 autores
- Thorsten U. Sauerwald🇺🇸Agricultural Research Service; Children's Nutrition Research Center at Baylor College of Medicine
- David L. Hachey🇺🇸Baylor College of Medicine; Children's Nutrition Research Center at Baylor College of Medicine
- Craig L. Jensen🇺🇸Baylor College of Medicine; Children's Nutrition Research Center at Baylor College of Medicine
- Huiming Chen🇺🇸Baylor College of Medicine
- Robert E. Anderson🇺🇸Baylor College of Medicine
- William C. Heird🇺🇸Baylor College of Medicine; Children's Nutrition Research Center at Baylor College of Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
An alternative pathway of omega 3 and omega 6 fatty acid metabolism has been described in isolated rate hepatocytes and human fibroblasts. This alternative pathway, which is independent of delta 4 desaturation, involves elongation of C22 5 omega 3 and C22:4 omega 6 to C24 fatty acids, delta 6 desaturation of the C24 fatty acids and subsequent beta oxidation of the desaturated products to C22:6 omega 3 and C22:5 omega 6. To determine whether this alternative pathway is operative in the human infant and also to obtain additional information concerning endogenous conversion of C18:3 omega 3 and C18:2 omega 6 to longer chain more unsaturated fatty acids, presence of [M + 18] isotopomers of omega 3 and omega 6 fatty acids in the plasma phospholipid fraction of term and preterm infants after administration of [U-13C]18:3 omega 3 and [U-13C]18:2 omega 6 was determined by negative chemical ionization gas chromatography/mass spectrometry. [M + 18] isotopomers of the following omega 3 fatty acids were detected: C18:3, C18:4, C20:3, C20:4, C20:5, C22:4, C22:5, C22:6, C24:4 (two infants only), C24:5, and C24:6. [M + 18] isotopomers of omega 6 fatty acids detected included only C18:2, C18:3, C20:2, C20:3, and C20:4, but sensitivity was insufficient to detect [M + 18] isotopomers of C22 and C24 omega 6 fatty acids. Presence of [M + 18] isotopomers of C24:5 omega 3 and C24:6 omega 3 indicates that these fatty acids were synthesized endogenously from C18:3 omega 3. This plus the in vitro data strongly suggests that infants use the recently described alternative pathway in endogenous synthesis of C22:6 omega 3. However, involvement also of delta 4 desaturation cannot be excluded. Detection of [M + 18] isotopomers of C20:3 omega 3, C20:2 omega 6, and C22:4 omega 3 suggests that C18:3 omega 3, C18:2 omega 6, and C20:4 omega 3 are elongated as well as desaturated. The specific fate of these elongation products and their importance in endogenous synthesis of omega 3 and omega 6 long chain polyunsaturated fatty acids remain to be determined.
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