Quantitative measurement of the effects of caffeine and propranolol on surgeon hand tremor
Humayun MU, Rader RS, Pieramici DJ, Awh CC, de Juan E
Archives of ophthalmology (Chicago, Ill. : 1960) · 44 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Eye Institute
- Gobierno
- NEI NIH HHS
- Subvenciones
- National Eye Institute (#EY01765)
Según 2 financiadores declarados.
Publicación
- Publicado
- 1997-03-01 · Arch Ophthalmol · vol. 115 · número 3 · pág. 371
- Editorial
- American Medical Association
- Citado
- 71 citas · más que el 87% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 11 trabajos
- Acceso
- De pago
- Áreas de investigación
- Surgical Simulation and Training · Coffee research and impacts · Motor Control and Adaptation
- Palabras clave
- hand tremor, caffeine, propranolol, beta-blockers, surgical performance, blood pressure, pulse rate, ophthalmic surgeons
- MeSH
- hand, humans, tremor, propranolol, caffeine, adrenergic beta-antagonists, central nervous system stimulants, microsurgery, double-blind method, ophthalmology, blood pressure, heart rate, female, male
1 autor
- Michael U. Humayun🇺🇸 · autor de correspondenciaJohns Hopkins University; Johns Hopkins Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To quantitatively measure the effects of caffeine and propranolol, a nonselective beta-blocking agent, on surgeon hand tremor during simulated vitreoretinal microsurgery.
Methods
Seventeen ophthalmic surgeons were tested on 3 separate days. On each day, subjects ingested 200 mg of caffeine, 10 mg of propranolol hydrochloride, or gelatin placebo. The drugs were administered as part of a double-masked, placebo-controlled trial. Hand tremor was measured using the Microsurgery Advanced Design Laboratory Stability, Activation, and Maneuverability tester (MADSAM), a high-resolution, noncontact position tracking system.
Results
The average percent magnitude changes from baseline tremor measurements were +15%, +31%, and -22% for placebo, caffeine, and propranolol groups, respectively. Analysis of variance techniques accounting for effects of individuals, drugs, and day order demonstrated that only drug effects on percent magnitude change of tremor were statistically significant (P = .01, F test). Detailed comparisons of the 2 drug groups with the placebo group revealed that, after adjusting for individual and order effects, only the mean decrease in tremor due to ingestion of propranolol was a statistically significant trend (P = .03, F test). Although caffeine caused a larger mean increase in percent magnitude change in tremor than placebo, this trend was not statistically significant (P = .34, F test). The evaluation of systemic physiologic measurements showed that there were statistically significant drug effects on percent change in systolic (P < .001, F test) and diastolic (P = .002, F test) blood pressure and pulse rate (P = .002, F test). Individual and day order effects were not significant. No adverse side effects were observed or reported in our test subjects.
Conclusion
Physiologic surgeon hand tremor can be decreased by the oral intake of a low dose of propranolol.
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