Casein phosphopeptides improve zinc and calcium absorption from rice-based but not from whole-grain infant cereal
Hansen M, Sandström B, Jensen M, Sørensen SS
Journal of pediatric gastroenterology and nutrition · 62 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
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Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1997-01-01 · J Pediatr Gastroenterol Nutr · vol. 24 · número 1 · págs. 56–62
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 105 citas · más que el 85% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Protein Hydrolysis and Bioactive Peptides · Infant Nutrition and Health · Proteins in Food Systems
- Palabras clave
- casein phosphopeptides, calcium absorption, zinc absorption, infant cereals, whole grain cereals, mineral bioavailability, dietary peptides, infant nutrition, whole-body retention
- MeSH
- humans, triticum, calcium, zinc, calcium radioisotopes, zinc radioisotopes, peptide fragments, phosphopeptides, caseins, biological availability, intestinal absorption, infant food, adult, infant, female, male, oryza
4 autores
- Marianne Hansen · autor de correspondencia
- Brittmarie Sandström
- Mikael Jensen🇩🇰Copenhagen University Hospital
- Sven Sølvsten Sørensen🇩🇰Copenhagen University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Casein phosphopeptides (CPP) are phosphorus-rich peptide fragments of casein, assumed to contribute to the high bioavailability of calcium from milk.
Methods
The effect of casein phosphopeptides on calcium and zinc absorption from infant foods was investigated. Twenty-two men and women were given single test meals extrinsically labeled with Ca and Zn. Absorption was calculated from measurements on whole-body retention of the radioisotopes. Each subject was given either rice-based cereal (n = 11) or whole-grain cereal (n = 11) on three occasions together with 250 ml water and added 0, 1, and 2 g CPP in random order. One serving of rice-based cereal contained 481 mg Ca and 1.29 mg Zn; whole-grain cereal contained 541 mg Ca and 1.77 mg Zn. One and 2 g of CPP contributed with additional 69 and 138 mg Ca, respectively.
Results
From rice-based cereal, fractional calcium absorption was not affected by CPP addition (mean +/- SD): 16.0 +/- 4.0% (no CPP), 17.6 +/- 4.5% (1 g CPP), and 15.8 +/- 4.3% (2 g CPP), while the total quantity of calcium absorbed was significantly improved: 7 +/- 19 mg, 97 +/- 25 mg, and 98 +/- 26 mg, respectively (p = 0.0004). Fractional zinc absorption as well as total quantity of zinc absorbed were increased with addition of CPP: 19.4 +/- 9.0% (0.25 +/- 0.12 mg), 25.2 +/- 7.5% (0.33 +/- 0.10 mg) and 23.9 +/- 5.4% (0.31 +/- 0.07 mg) at the three CPP levels (p = 0.04). From whole-grain cereal, CPP had no effect on the percentage or actual quantity of calcium absorbed: 17.0 +/- 3.2% (92 +/- 18 mg), 17.2 +/- 4.5% (105 +/- 27 mg), and 15.0 +/- 4.6% (102 +/- 31 mg), respectively. Zinc absorption was also not influenced by CPP: 16.0 +/- 5.1% (0.28 +/- 0.09 mg), 15.3 +/- 3.1% (0.27 +/- 0.06 mg) and 18.1 +/- 4.4% (0.32 +/- 0.08 mg), respectively.
Conclusions
CPP addition improved calcium and zinc absorption from rice-based cereal, while no effect was seen from whole-grain cereal.
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