Plasma lipid and lipoprotein responses to dietary fat and cholesterol: a meta-analysis
Howell WH, McNamara DJ, Tosca MA, Smith BT, Gaines JA
The American journal of clinical nutrition · 176 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1997-06-01 · Am J Clin Nutr · vol. 65 · número 6 · págs. 1747–1764
- Editorial
- Elsevier BV
- Citado
- 343 citas · más que el 92% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 244 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Cholesterol and Lipid Metabolism · Nutritional Studies and Diet
- Palabras clave
- dietary fat, dietary cholesterol, plasma lipids, serum cholesterol, triglycerides, lipoprotein cholesterol, LDL cholesterol, HDL cholesterol, VLDL cholesterol, dietary recommendations, dietary adherence
- MeSH
- humans, cholesterol, lipids, dietary fats, cholesterol, dietary, triglycerides, lipoproteins, diet, regression analysis, predictive value of tests, models, biological, adolescent, adult, aged, middle aged, united states, female, male, patient education as topic, guidelines as topic
5 autores
- WH Howell🇺🇸 · autor de correspondenciaUniversity of Arizona
- DJ McNamara🇺🇸University of Arizona
- MA Tosca🇺🇸University of Arizona
- BT Smith🇺🇸University of Arizona
- JA Gaines🇺🇸University of Arizona
Resumen
El texto original del estudio, en el idioma en que se publicó.
Quantitative relations between dietary fat and cholesterol and plasma lipid concentrations have been the subject of much study and some controversy during the past 40 y. Previous meta-analyses have focused on the most tightly controlled, highest-quality experiments. To test whether the findings of these investigations are generalizable to broader experimental settings and to the design of practical dietary education interventions, data from 224 published studies on 8143 subjects in 366 independent groups including 878 diet-blood lipid comparisons were subjected to weighted multiple-regression analysis. Inclusion criteria specified intervention studies published in English between 1966 and 1994 reporting quantitative data on changes in dietary cholesterol and fat and corresponding changes in serum cholesterol, triacylglycerol, and lipoprotein cholesterol concentrations. Regression models are reported for serum total cholesterol, triacylglycerol, and low-density-high-density-, and very-low-density-lipoprotein cholesterol, with multiple correlations of 0.74, 0.65, 0.41, 0.14, and 0.34, respectively. Interactions of dietary factors, initial dietary intakes and serum concentrations, and study and subject characteristics had little effect on these models. Predictions indicated that compliance with current dietary recommendations (30% of energy from fat, < 10% from saturated fat, and < 300 mg cholesterol/d) will reduce plasma total and low-density-lipoprotein-cholesterol concentrations by approximately 5% compared with amounts associated with the average American diet.
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