Caffeine enhances modulation of parasympathetic nerve activity in humans: quantification using power spectral analysis
Hibino G, Moritani T, Kawada T, Fushiki T
The Journal of nutrition · 53 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1997-07-01 · J Nutr · vol. 127 · número 7 · págs. 1422–1427
- Editorial
- Elsevier BV
- Citado
- 98 citas · más que el 68% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Heart Rate Variability and Autonomic Control · Coffee research and impacts · Vagus Nerve Stimulation Research
- Palabras clave
- caffeine, parasympathetic nervous system, parasympathetic activity, heart rate variability, RR interval, power spectrum analysis, high-frequency power, autonomic nervous system activity, decaffeinated coffee, caffeine consumption
- MeSH
- autonomic nervous system, vagus nerve, parasympathetic nervous system, humans, caffeine, central nervous system stimulants, body temperature, analysis of variance, area under curve, cross-over studies, sleep, body temperature regulation, blood pressure, heart rate, eating, dose-response relationship, drug, fourier analysis, time factors, adult, female, male
4 autores
- Gaku Hibino🇯🇵Kyoto University
- Toshio Moritani🇯🇵Kyoto University
- Teruo Kawada🇯🇵Kyoto University
- Tohru Fushiki🇯🇵 · autor de correspondenciaKyoto University
Resumen
El texto original del estudio, en el idioma en que se publicó.
We investigated changes in autonomic nerve activity following caffeine intake by power spectral analysis of R-R intervals of heartbeats in humans. A beverage containing 240 mg of caffeine or a control beverage was given to 10 healthy volunteers, and R-R intervals were measured while subjects were sitting and controlling their respiration at a constant rate. After consumption of the caffeine-containing beverage, a transient and significant increase (P < 0.001) in spectral integrated values (areas under the curve) of high frequency power (high component, HC) was observed, and at 30 min the value was significantly greater than in controls (P < 0.02), suggesting an increase in vagal autonomic nerve activity. The effect of caffeine was also examined using decaffeinated coffee supplemented with exogenous caffeine (2 mg/kg body wt). A transient and significant increase (P < 0.0001) in HC was observed, and the value was significantly greater (P < 0.02) than when subjects consumed decaffeinated coffee without supplemental caffeine. The ratio of HC to total integrated value (which is also used as a selective indicator of vagal activity) was also significantly higher (P < 0.04) after caffeine consumption. Physiological variables accompanying the change in autonomic nerve activity (i.e., blood pressure, surface body temperature and heart rate) were not significantly affected by caffeine intake. These results suggest that power spectral analysis of heartbeat R-R intervals is an effective and noninvasive method for detecting subtle changes in autonomic nerve activity in response to food intake.
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