Positive human health effects of dust suppression with canola oil in swine barns
Senthilselvan A, Zhang Y, Dosman JA, Barber EM, Holfeld LE, Kirychuk SP, Cormier Y, Hurst TS, Rhodes CS
American journal of respiratory and critical care medicine · 39 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1997-08-01 · Am J Respir Crit Care Med · vol. 156 · número 2 · págs. 410–417
- Editorial
- American Thoracic Society
- Citado
- 66 citas · más que el 91% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- De pago
- Áreas de investigación
- Indoor Air Quality and Microbial Exposure · Occupational exposure and asthma · Air Quality and Health Impacts
- Palabras clave
- dust control, canola oil, swine barns, pig housing, indoor air quality, endotoxin, inhalable dust, lung function, airway hyperresponsiveness, methacholine challenge, neutrophilia, serum cytokines, occupational exposure, respiratory effects
- MeSH
- animals, swine, humans, agricultural workers' diseases, fatty acids, monounsaturated, dust, respiratory function tests, cross-over studies, housing, animal, air pollution, indoor, time factors, animal husbandry, adolescent, adult, saskatchewan, male, surveys and questionnaires, rapeseed oil
9 autores
- Ambikaipakan Senthilselvan🇺🇸🇨🇦University of Illinois Urbana-Champaign; University of Saskatchewan; Université Laval
- Yuanhui Zhang🇺🇸🇨🇦University of Illinois Urbana-Champaign; University of Saskatchewan; Université Laval
- J A Dosman🇺🇸🇨🇦University of Illinois Urbana-Champaign; University of Saskatchewan; Université Laval
- E. M. Barber🇺🇸🇨🇦University of Illinois Urbana-Champaign; University of Saskatchewan; Université Laval
- L. E. HOLFELD🇺🇸🇨🇦University of Illinois Urbana-Champaign; University of Saskatchewan; Université Laval
- Shelley Kirychuk🇺🇸🇨🇦University of Illinois Urbana-Champaign; University of Saskatchewan; Université Laval
- Yvon F. Cormier🇺🇸🇨🇦University of Illinois Urbana-Champaign; University of Saskatchewan; Université Laval
- Thomas S. Hurst🇺🇸🇨🇦University of Illinois Urbana-Champaign; University of Saskatchewan; Université Laval
- Carrie Rhodes🇺🇸🇨🇦University of Illinois Urbana-Champaign; University of Saskatchewan; Université Laval
Resumen
El texto original del estudio, en el idioma en que se publicó.
A crossover trial was conducted to evaluate the acute human health effects of a dust control technology in a swine confinement facility. Twenty lifetime nonsmoking male subjects, with no evidence of allergy or asthma and no previous swine barn exposure, participated in the study, which included a laboratory session (baseline), 5-h exposure in a swine room sprinkled with canola oil (treatment) and 5-h exposure in a traditional swine room (control). Mean values of inhalable dust concentrations and endotoxin levels in the control room were significantly greater than those observed in the treatment room. Mean shift changes in FEV1 from preexposure to end of exposure were 1.1% (standard error, 0.63%) on baseline day, -1.9% (0.63%) on treatment day, and -9.9% (1.12%) on control day; the differences in the shift changes were statistically significant. Mean value of methacholine concentration that reduced the FEV1 by 20% (PC20) in bronchoprovocation tests on baseline day was significantly different from that on treatment day (p = 0.04) and that on control day (p < 0.001). Significant increases were also observed in white blood cell counts and nasal lavage cell counts on the control day in comparison with the other two days. Blood neutrophil counts after control room exposure were twice those observed on baseline and after exposure to the treatment room. Significant differences were also observed in IL-1 beta, IL-6, and IL-8 nasal lavage cytokines and in IL-6 serum cytokine. These results suggest that the canola oil dust control method is effective in improving indoor air quality in swine barns and reducing acute health effects in naive healthy subjects.
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