Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival--4
Singh RB, Niaz MA, Sharma JP, Kumar R, Rastogi V, Moshiri M
Cardiovascular drugs and therapy · 302 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1997-07-01 · Cardiovasc Drugs Ther · vol. 11 · número 3 · págs. 485–491
- Editorial
- Springer Science+Business Media
- Citado
- 536 citas · más que el 99% de estudios similares · 14.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Acute Myocardial Infarction Research · Edible Oils Quality and Analysis
- Palabras clave
- fish oil, mustard oil, acute myocardial infarction, eicosapentaenoic acid, alpha-linolenic acid, omega-3 fatty acids, lipid peroxidation, conjugated dienes, oxidative stress, cardiac events, cardiac mortality, cardiac arrhythmias, angina pectoris, left ventricular dilatation, serum lipoproteins
- MeSH
- myocardium, heart, humans, mustard plant, plants, medicinal, hypertrophy, left ventricular, angina pectoris, myocardial infarction, docosahexaenoic acids, eicosapentaenoic acid, triglycerides, lipoproteins, fish oils, plant oils, plant extracts, drug combinations, follow-up studies, double-blind method, lipid peroxidation, oxidative stress, adult, aged, middle aged, india, female, male, cholesterol, hdl, arrhythmias, cardiac
6 autores
- Ram Bahadur Singh
- Mohammad Arif Niaz🇮🇷Shaheed Rajaei Cardiovascular Medical and Research Center
- Jagdish P. Sharma🇮🇷Shaheed Rajaei Cardiovascular Medical and Research Center
- Rakesh Kumar🇮🇷Shaheed Rajaei Cardiovascular Medical and Research Center
- Vipul Rastogi🇮🇷Shaheed Rajaei Cardiovascular Medical and Research Center
- Mahmood Moshiri🇮🇷Shaheed Rajaei Cardiovascular Medical and Research Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
In a randomized, placebo-controlled trial, the effects of treatment with fish oil (eicosapentaenoic acid, 1.08 g/day) and mustard oil (alpha-linolenic acid, 2.9 g/day) were compared for 1 year in the management of 122 patients (fish oil, group A), 120 patients (mustard oil, group B), and 118 patients (placebo, group C) with suspected acute myocardial infarction (AMI). Treatments were administered about (mean) 18 hours after the symptoms of AMI in all three groups. The extent of cardiac disease, rise in cardiac enzymes, and lipid peroxides were comparable among the groups at entry into the study. After 1 year total cardiac events were significantly less in the fish oil and mustard oil groups compared with the placebo group (24.5% and 28% vs. 34.7%, p < 0.01). Nonfatal infarctions were also significantly less in the fish oil and mustard oil groups compared with the placebo group (13.0% and 15.0% vs. 25.4%, p < 0.05). Total cardiac deaths showed no significant reduction in the mustard oil group; however, the fish oil group had significantly less cardiac deaths compared with the placebo group (11.4% vs. 22.0%, p < 0.05). Apart from the decrease in the cardiac event rate, the fish oil and mustard oil groups also showed a significant reduction in total cardiac arrhythmias, left ventricular enlargement, and angina pectoris compared with the placebo group. Reductions in blood lipoproteins in the two intervention groups were modest and do not appear to be the cause of the benefit in the two groups. Diene conjugates showed a significant reduction in the fish oil and mustard oil groups, indicating that a part of the benefit may be caused by the reduction in oxidative stress. The findings of this study suggest that fish oil and mustard oil, possibly due to the presence of n-3 fatty acids, may provide rapid protective effects in patients with AMI. However, a large study is necessary to confirm this suggestion.
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