Absorption and subjective effects of caffeine from coffee, cola and capsules
Liguori A, Hughes JR, Grass JA
Pharmacology, biochemistry, and behavior · 85 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Aging
- Gobierno
- National Institute on Drug Abuse
- Gobierno
- NIDA NIH HHS
- Subvenciones
- National Institute on Drug Abuse (DA-04843); National Institute on Drug Abuse (DA00109)
Según 3 financiadores declarados.
Publicación
- Publicado
- 1997-11-01 · Pharmacol Biochem Behav · vol. 58 · número 3 · págs. 721–726
- Editorial
- Elsevier BV
- Citado
- 168 citas · más que el 68% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 29 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Sleep and Work-Related Fatigue · Neurotransmitter Receptor Influence on Behavior
- Palabras clave
- caffeine, coffee, cola, subjective effects, vehicle effects, caffeine dose
- MeSH
- saliva, humans, substance withdrawal syndrome, caffeine, central nervous system stimulants, capsules, area under curve, double-blind method, behavior, affect, dose-response relationship, drug, carbonated beverages, coffee, adult, female, male
1 autor
- Anthony Liguori🇺🇸 · autor de correspondenciaUniversity of Vermont
Resumen
El texto original del estudio, en el idioma en que se publicó.
Coffee is often perceived as producing greater pharmacological effects than cola. The present study compared the magnitude and rapidity of peak caffeine levels and subjective effects between coffee and cola. Thirteen users of both coffee and cola (mean daily caffeine consumption = 456 mg) ingested 400 mg caffeine via 12 oz unsweetened coffee, 24 oz sugar-free cola or 2 capsules in a random, double-blind, placebo-controlled, within-subjects design. Subjects provided a saliva sample and completed subjective effect scales 15 min before and 30, 60, 90, 120, 180 and 240 min after ingestion. Mean peak saliva caffeine levels did not differ between coffee (9.7 +/- 1.2 micrograms/ml) and cola (9.8 +/- 0.9 micrograms/ml) and appeared to be greater with these beverages than with the capsule (7.8 +/- 0.6 micrograms/ml; p = NS). Saliva caffeine levels peaked at similar times for coffee (42 +/- 5 min) and cola (39 +/- 5 min) but later for capsule (67 +/- 7 min; p = 0.004). There was no main effect of vehicle or interaction of vehicle and drug on magnitude of peak effect or time to peak increase on self-report scales. In summary, peak caffeine absorption, time to peak absorption, and subjective effects do not appear to be influenced by cola vs. coffee vehicle. Perceived differences in the effects of coffee vs. cola may be due to differences in dose, time of day, added sweetener, environmental setting or contingencies.
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