Dose-dependent pharmacokinetics and psychomotor effects of caffeine in humans
Kaplan GB, Greenblatt DJ, Ehrenberg BL, Goddard JE, Cotreau MM, Harmatz JS, Shader RI
Journal of clinical pharmacology · 250 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Aging
- Gobierno
- National Institute of Mental Health
- Gobierno
- National Center for Research Resources
- Gobierno
- NIA NIH HHS
- Gobierno
- NCRR NIH HHS
- Gobierno
- NIMH NIH HHS
- Subvenciones
- National Center for Research Resources (RR00054); National Institute of Mental Health (MH 34223); National Institute on Aging (AG-00106)
Según 6 financiadores declarados.
Publicación
- Publicado
- 1997-08-01 · J Clin Pharmacol · vol. 37 · número 8 · págs. 693–703
- Editorial
- Wiley
- Citado
- 386 citas · más que el 95% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Sleep and Work-Related Fatigue · Alkaloids: synthesis and pharmacology
- Palabras clave
- caffeine, nonlinear pharmacokinetics, caffeine clearance, elimination half-life, psychomotor effects, subjective effects, anxiety, cognitive performance, motor performance, Digit Symbol Substitution Test, tapping speed, stimulants
- MeSH
- humans, caffeine, central nervous system stimulants, area under curve, double-blind method, psychomotor performance, dose-response relationship, drug, half-life, adult, female, male
7 autores
- Gary B. Kaplan🇺🇸 · autor de correspondenciaBrown University; Providence VA Medical Center
- David J. Greenblatt🇺🇸Tufts University; Tufts Medical Center
- Bruce L. Ehrenberg🇺🇸Tufts University; Tufts Medical Center
- Jill E. Goddard🇺🇸Tufts University; Tufts Medical Center
- Monette M Cotreau🇺🇸Tufts University; Tufts Medical Center
- Jerold S. Harmatz🇺🇸Tufts University; Tufts Medical Center
- Richard I. Shader🇺🇸Tufts University; Tufts Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Twelve healthy volunteers received oral placebo, 250 mg of caffeine, and 500 mg of caffeine in a randomized, double-blind, single-dose crossover study. Caffeine kinetics were nonlinear, with clearance significantly reduced and elimination half-life prolonged at the 500-mg compared to the 250-mg dose. The lower dose of caffeine produced more favorable subjective effects than the higher dose (elation, peacefulness, pleasantness), whereas unpleasant effects (tension, nervousness, anxiety, excitement, irritability, nausea, palpitations, restlessness) following the 500-mg dose exceeded those of the 250-mg dose. The lower dose of caffeine enhanced performance on the digit symbol substitution test and a tapping speed test compared to placebo; high-dose caffeine produced less performance enhancement than the lower dose. The plasma concentration versus response relationship revealed concentration-dependent increases in anxiety and improvements in cognitive and motor performance at low to intermediate concentrations. Both caffeine doses reduced electroencephalographic amplitude over the 4 Hz to 30 Hz spectrum, as well as in the alpha (8-11 Hz) and beta (12-30 Hz) ranges; however, effects were not dose-dependent. While favorable subjective and performance-enhancing stimulant effects occur at low to intermediate caffeine doses, the unfavorable subjective and somatic effects, as well as performance disruption, from high doses of caffeine may intrinsically limit the doses of caffeine used in the general population.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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