The effects of high oral magnesium supplementation on blood pressure, serum lipids and related variables in apparently healthy Japanese subjects
Itoh K, Kawasaka T, Nakamura M
The British journal of nutrition · 63 citas
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Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1997-11-01 · Br J Nutr · vol. 78 · número 5 · págs. 737–750
- Editorial
- Cambridge University Press
- Citado
- 109 citas · más que el 91% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Blood Pressure and Hypertension Studies · Magnesium Oxide Properties and Applications
- Palabras clave
- magnesium supplementation, magnesium hydroxide, blood pressure, serum lipids, urinary magnesium excretion, sodium excretion, aldosterone, norepinephrine, lecithin:cholesterol acyltransferase, HDL cholesterol, apolipoprotein A-I, adrenergic activity, healthy adults
- MeSH
- humans, sodium, magnesium, norepinephrine, cholesterol, aldosterone, phosphatidylcholine-sterol o-acyltransferase, lipids, apolipoprotein a-i, hematocrit, administration, oral, double-blind method, enzyme activation, blood pressure, diastole, aged, middle aged, female, male, cholesterol, hdl
3 autores
- Kazue Itoh🇯🇵Nakamura Gakuen University
- Terukazu Kawasaki🇯🇵Kyushu University
- Motoomi Nakamura🇯🇵Nakamura Gakuen University
Resumen
El texto original del estudio, en el idioma en que se publicó.
In a double-blind, placebo-controlled study, thirty-three subjects were allocated to undergo either a 4-week treatment with oral Mg supplementation (Mg(OH)2; 411-548 mg Mg/d) or a placebo. The urinary excretion of Mg increased significantly in both the first 2 weeks and the following 2 weeks of Mg supplementation, while the urinary Na excretion also increased significantly over the experimental period. The systolic and diastolic blood pressure values decreased significantly in the Mg group, but not in the placebo group. The urinary aldosterone excretion and packed cell volume increased significantly during the last 2 weeks of the experimental period compared with the run-in period and first 2 weeks of supplementation. There was a statistically significant positive correlation between the values for urinary noradrenaline excretion and diastolic blood pressure at the end of the supplementation period (both expressed as a percentage of the run-in value). Statistically significant increases in lecithin-cholesterol acyltransferase (EC 2.3.1.43; LCAT), HDL-cholesterol and apolipoprotein AI were also observed after Mg supplementation. A significant positive correlation was observed between the levels of LCAT and urinary Mg excretion for the experimental period (expressed as a percentage of the run-in value). The total cholesterol:HDL-cholesterol ratio decreased significantly during the last 2 weeks of Mg supplementation compared with the first 2 weeks and the run-in periods, but this did not occur in the placebo group. These results suggest that Mg supplementation may lower blood pressure through the suppression of the adrenergic activity and possible natriuresis, while also improving the serum lipids through the activation of LCAT in human subjects.
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