Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial
Gogos CA, Ginopoulos P, Salsa B, Apostolidou E, Zoumbos NC, Kalfarentzos F
Cancer · 163 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1998-01-15 · Cancer · vol. 82 · número 2 · págs. 395–402
- Editorial
- Wiley
- Citado
- 311 citas · más que el 99% de estudios similares · 13.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Clinical Nutrition and Gastroenterology · Nutrition and Health in Aging
- Palabras clave
- omega-3 polyunsaturated fatty acids, fish oil supplementation, vitamin E, malnutrition, immunodeficiency, tumor immunomodulation, natural killer cells, cytokine production, TNF-α, interleukin-1, interleukin-6, survival, solid tumors, nutritional status
- MeSH
- leukocytes, mononuclear, killer cells, natural, t-lymphocytes, t-lymphocytes, helper-inducer, humans, neoplasms, nutrition disorders, critical illness, vitamin e, fatty acids, omega-3, tumor necrosis factor-alpha, interleukin-1, interleukin-6, adjuvants, immunologic, placebos, lymphocyte count, karnofsky performance status, survival rate, follow-up studies, prospective studies, immunocompromised host, nutritional status, dietary supplements, middle aged, female, male, t-lymphocytes, regulatory
6 autores
- Charalambos A. Gogos🇬🇷 · autor de correspondenciaUniversity of Patras
- Panayiotis Ginopoulos🇬🇷University of Patras
- Bassilis Salsa🇬🇷University of Patras
- Euterpi Apostolidou🇬🇷University of Patras
- Nikolas C. Zoumbos🇬🇷University of Patras
- Fotis E. Kalfarentzos🇬🇷University of Patras
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The aim of the current prospective, randomized control study was to investigate the effect of dietary omega-3 polyunsaturated fatty acids plus vitamin E on the immune status and survival of well-nourished and malnourished patients with generalized malignancy.
Methods
Sixty patients with generalized solid tumors were randomized to receive dietary supplementation with either fish oil (18 g of omega-3 polyunsaturated fatty acids, PUFA) or placebo daily until death. Each group included 15 well-nourished and 15 malnourished patients. The authors measured total T cells, T-helper cells, T-suppressor cells, natural killer cells, and the synthesis of interleukin-1, interleukin-6, and tumor necrosis factor by peripheral blood mononuclear cells before and on Day 40 of fish oil supplementation. Karnofsky performance status, nutritional state, and survival were also estimated.
Results
The ratio of T-helper cells to T-suppressor cells was significantly lower in malnourished patients. Omega-3 PUFA had a considerable immunomodulating effect by increasing this ratio in the subgroup of malnourished patients. There were no significant differences in cytokine production among the various groups, except for a decrease in tumor necrosis factor production in malnourished cancer patients, which was restored by omega-3 fatty acids. The mean survival was significantly higher for the subgroup of well-nourished patients in both groups, whereas omega-3 fatty acids prolonged the survival of all the patients.
Conclusions
Malnutrition appears to be an important predictor of survival for patients with end stage malignant disease. Omega-3 polyunsaturated fatty acids had a significant immunomodulating effect and seemed to prolong the survival of malnourished patients with generalized malignancy.
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