Pro- and anti-inflammatory cytokines in healthy volunteers fed various doses of fish oil for 1 year
Blok WL, Deslypere JP, Demacker PN, van der Ven-Jongekrijg J, Hectors MP, van der Meer JW, Katan MB
European journal of clinical investigation · 95 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1997-12-01 · Eur J Clin Invest · vol. 27 · número 12 · págs. 1003–1008
- Editorial
- Wiley
- Citado
- 129 citas · más que el 84% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Inflammatory mediators and NSAID effects
- Palabras clave
- fish oil, omega-3 fatty acids, dietary supplementation, inflammatory cytokines, anti-inflammatory cytokines, IL-1β, TNF-α, interleukin-6, interleukin-1 receptor antagonist, whole blood cytokine production, endotoxin stimulation, erythrocyte fatty acids, long-term supplementation, healthy volunteers
- MeSH
- humans, inflammation, fish oils, sialoglycoproteins, tumor necrosis factor-alpha, interleukin-1, cytokines, patient compliance, dietary supplements, adult, aged, aged, 80 and over, middle aged, male, interleukin 1 receptor antagonist protein
7 autores
- Willem L. Blok🇳🇱Radboud University Nijmegen
- J.‐P. DESLYPERE🇧🇪Ghent University Hospital
- Pierre N.M. Demacker · autor de correspondencia
- Johanna van der Ven‐Jongekrijg
- M.P.C. Hectors
- Jos W. M. van der Meer
- Mira Katan🇳🇱Wageningen University & Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary supplementation with n-3 fatty acids from fish oil alleviates inflammation in various chronic inflammatory disease states. Reductions in the production of pro-inflammatory cytokines interleukin 1 beta (IL-1 beta), tumour necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) have been seen in humans after short-term n-3 fatty acid supplementation. We investigated long-term effects of dietary n-3 fatty acids on circulating cytokine concentrations and on ex vivo stimulated whole-blood production of IL-1 beta, TNF-alpha and interleukin 1 receptor antagonist (IL-1Ra), the naturally occurring antagonist of IL-1. A total of 58 monks with a mean age of 56 years were randomized into four groups and their diets were supplemented with 0, 3, 6, or 9 g of fish oil, providing 0, 1.06, 2.13 or 3.19 g of n-3 fatty acids per day. Subjects received equal amounts of saturated fatty acids, vitamin E and cholesterol. Compliance was excellent and erythrocyte fatty acid profiles closely reflected the amounts of n-3 fatty acids ingested. In the group receiving 9 g of fish oil per day, no influence of n-3 fatty acids on circulating cytokine concentrations was observed relative to placebo. Endotoxin-stimulated whole-blood cytokine production was measured at 26 and 52 weeks after the start and at 4, 8 and 26 weeks after cessation of supplementation. In all groups, the production of IL-1 beta and IL-1Ra was higher during supplementation than afterwards. However, no differences in cytokine production were noted between the placebo group and the various treatment groups at any point in time. Our results suggest that long-term supplementation of fish oil does not affect ex vivo cytokine production in man.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.