Effects of reducing dietary saturated fatty acids on plasma lipids and lipoproteins in healthy subjects: the DELTA Study, protocol 1
Ginsberg HN, Kris-Etherton P, Dennis B, Elmer PJ, Ershow A, Lefevre M, Pearson T, Roheim P, Ramakrishnan R, Reed R, Stewart K, Stewart P, Phillips K, Anderson N
Arteriosclerosis, thrombosis, and vascular biology · 191 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (49648); National Heart, Lung, and Blood Institute (5-U01-HL-49648); National Heart, Lung, and Blood Institute (5-U01-HL-49649); National Heart, Lung, and Blood Institute (49659); National Heart, Lung, and Blood Institute (5-U01-HL-49644); National Heart, Lung, and Blood Institute (49651); National Heart, Lung, and Blood Institute (49649); National Institutes of Health (M01RR00400)
Según 4 financiadores declarados.
Publicación
- Publicado
- 1998-03-01 · Arterioscler Thromb Vasc Biol · vol. 18 · número 3 · págs. 441–449
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 294 citas · más que el 100% de estudios similares · 17.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 75 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Lipoproteins and Cardiovascular Health · Nutritional Studies and Diet
- Palabras clave
- saturated fatty acids, dietary fat reduction, plasma lipids, lipoproteins, LDL cholesterol, HDL cholesterol, total cholesterol, triglycerides, lipoprotein(a), postmenopausal women, Black people, older men, dietary intervention, controlled feeding study, sex differences, racial differences, age differences
- MeSH
- humans, lipids, dietary fats, fatty acids, lipoproteins, cross-over studies, double-blind method, sex characteristics, postmenopause, premenopause, reference values, adult, aged, middle aged, female, male, black people
14 autores
- Henry N. Ginsberg🇺🇸Pennington Biomedical Research Center; University of North Carolina at Chapel Hill; Louisiana State University; National Institutes of Health; University of Minnesota; Pennsylvania State University; National Heart, Lung, and Blood Institute; Bassett Medical Center; Columbia University; Virginia Tech
- Penny M. Kris‐Etherton🇺🇸Pennington Biomedical Research Center; University of North Carolina at Chapel Hill; Louisiana State University; National Institutes of Health; University of Minnesota; Pennsylvania State University; National Heart, Lung, and Blood Institute; Bassett Medical Center; Columbia University; Virginia Tech
- Barbara Dennis🇺🇸Pennington Biomedical Research Center; University of North Carolina at Chapel Hill; Louisiana State University; National Institutes of Health; University of Minnesota; Pennsylvania State University; Columbia University Irving Medical Center; National Heart, Lung, and Blood Institute; Bassett Medical Center; Columbia University; Virginia Tech
- Patricia J. Elmer🇺🇸Pennington Biomedical Research Center; University of North Carolina at Chapel Hill; Louisiana State University; National Institutes of Health; University of Minnesota; Pennsylvania State University; Columbia University Irving Medical Center; National Heart, Lung, and Blood Institute; Bassett Medical Center; Columbia University; Virginia Tech
- Abby G. Ershow🇺🇸Pennington Biomedical Research Center; University of North Carolina at Chapel Hill; Louisiana State University; National Institutes of Health; University of Minnesota; Pennsylvania State University; Columbia University Irving Medical Center; National Heart, Lung, and Blood Institute; Bassett Medical Center; Columbia University; Virginia Tech
- Michael L LeFevre🇺🇸Pennington Biomedical Research Center; University of North Carolina at Chapel Hill; Louisiana State University; National Institutes of Health; University of Minnesota; Pennsylvania State University; National Heart, Lung, and Blood Institute; Bassett Medical Center; Columbia University; Virginia Tech
- Thomas A. Pearson🇺🇸Pennington Biomedical Research Center; University of North Carolina at Chapel Hill; Louisiana State University; National Institutes of Health; University of Minnesota; Pennsylvania State University; Columbia University Irving Medical Center; National Heart, Lung, and Blood Institute; Bassett Medical Center; Columbia University; Virginia Tech
- Paul S. Roheim🇺🇸Pennington Biomedical Research Center; University of North Carolina at Chapel Hill; Louisiana State University; National Institutes of Health; University of Minnesota; Pennsylvania State University; Columbia University Irving Medical Center; National Heart, Lung, and Blood Institute; Bassett Medical Center; Columbia University; Virginia Tech
- Rajasekhar Ramakrishnan🇺🇸Pennington Biomedical Research Center; University of North Carolina at Chapel Hill; Louisiana State University; National Institutes of Health; University of Minnesota; Pennsylvania State University; Columbia University Irving Medical Center; National Heart, Lung, and Blood Institute; Bassett Medical Center; Columbia University; Virginia Tech
- Roberta G. Reed🇺🇸Pennington Biomedical Research Center; University of North Carolina at Chapel Hill; Louisiana State University; National Institutes of Health; University of Minnesota; Pennsylvania State University; Columbia University Irving Medical Center; National Heart, Lung, and Blood Institute; Bassett Medical Center; Columbia University; Virginia Tech
- Kent K. Stewart🇺🇸Pennington Biomedical Research Center; University of North Carolina at Chapel Hill; Louisiana State University; National Institutes of Health; University of Minnesota; Pennsylvania State University; Columbia University Irving Medical Center; National Heart, Lung, and Blood Institute; Bassett Medical Center; Columbia University; Virginia Tech
- Paul W. Stewart🇺🇸Pennington Biomedical Research Center; University of North Carolina at Chapel Hill; Louisiana State University; National Institutes of Health; University of Minnesota; Pennsylvania State University; Columbia University Irving Medical Center; National Heart, Lung, and Blood Institute; Bassett Medical Center; Columbia University; Virginia Tech
- Katherine M. Phillips🇺🇸Pennington Biomedical Research Center; University of North Carolina at Chapel Hill; Louisiana State University; National Institutes of Health; University of Minnesota; Pennsylvania State University; Columbia University Irving Medical Center; National Heart, Lung, and Blood Institute; Bassett Medical Center; Columbia University; Virginia Tech
- Nancy Anderson🇺🇸Pennington Biomedical Research Center; University of North Carolina at Chapel Hill; Louisiana State University; National Institutes of Health; University of Minnesota; Pennsylvania State University; Columbia University Irving Medical Center; National Heart, Lung, and Blood Institute; Bassett Medical Center; Columbia University; Virginia Tech
Resumen
El texto original del estudio, en el idioma en que se publicó.
Few well-controlled diet studies have investigated the effects of reducing dietary saturated fatty acid (SFA) intake in premenopausal and postmenopausal women or in blacks. We conducted a multicenter, randomized, crossover-design trial of the effects of reducing dietary SFA on plasma lipids and lipoproteins in 103 healthy adults 22 to 67 years old. There were 46 men and 57 women, of whom 26 were black, 18 were postmenopausal women, and 16 were men > or =40 years old. All meals and snacks, except Saturday dinner, were prepared and served by the research centers. The study was designed to compare three diets: an average American diet (AAD), a Step 1 diet, and a low-SFA (Low-Sat) diet. Dietary cholesterol was constant. Diet composition was validated and monitored by a central laboratory. Each diet was consumed for 8 weeks, and blood samples were obtained during weeks 5 through 8. The compositions of the three diets were as follows: AAD, 34.3% kcal fat and 15.0% kcal SFA; Step 1, 28.6% kcal fat and 9.0% kcal SFA; and Low-Sat, 25.3% kcal fat and 6.1% kcal SFA. Each diet provided approximately 275 mg cholesterol/d. Compared with AAD, plasma total cholesterol in the whole group fell 5% on Step 1 and 9% on Low-Sat. LDL cholesterol was 7% lower on Step 1 and 11% lower on Low-Sat than on the AAD (both P<.01). Similar responses were seen in each subgroup. HDL cholesterol fell 7% on Step 1 and 11% on Low-Sat (both P<.01). Reductions in HDL cholesterol were seen in all subgroups except blacks and older men. Plasma triglyceride levels increased approximately 9% between AAD and Step 1 but did not increase further from Step 1 to Low-Sat. Changes in triglyceride levels were not significant in most subgroups. Surprisingly, plasma Lp(a) concentrations increased in a stepwise fashion as SFA was reduced. In a well-controlled feeding study, stepwise reductions in SFA resulted in parallel reductions in plasma total and LDL cholesterol levels. Diet effects were remarkably similar in several subgroups of men and women and in blacks. The reductions in total and LDL cholesterol achieved in these different subgroups indicate that diet can have a significant impact on risk for atherosclerotic cardiovascular disease in the total population.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.