Influence of arginine, omega-3 fatty acids and nucleotide-supplemented enteral support on systemic inflammatory response syndrome and multiple organ failure in patients after severe trauma
Weimann A, Bastian L, Bischoff WE, Grotz M, Hansel M, Lotz J, Trautwein C, Tusch G, Schlitt HJ, Regel G
Nutrition (Burbank, Los Angeles County, Calif.) · 79 citas
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Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 1998-02-01 · Nutrition · vol. 14 · número 2 · págs. 165–172
- Editorial
- Elsevier BV
- Citado
- 150 citas · más que el 99% de estudios similares · 9.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Sepsis Diagnosis and Treatment · Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Palabras clave
- L-arginine, omega-3 fatty acids, nucleotides, enteral nutrition, systemic inflammatory response syndrome, multiple organ failure, severe trauma, critically ill patients, C-reactive protein, fibrinogen, HLA-DR expression, monocytes, interleukin-2 receptor, infection rate, mortality
- MeSH
- monocytes, humans, wounds and injuries, acute-phase reaction, multiple organ failure, nucleotides, fatty acids, omega-3, arginine, c-reactive protein, hla-dr antigens, enteral nutrition, adolescent, adult, middle aged, systemic inflammatory response syndrome
10 autores
- Arved Weimann🇩🇪 · autor de correspondenciaMedizinische Hochschule Hannover
- Leonard Bastian🇩🇪Medizinische Hochschule Hannover
- Werner E. Bischoff🇩🇪Medizinische Hochschule Hannover
- M. Grotz🇩🇪Medizinische Hochschule Hannover
- Matthias Hansel🇩🇪Medizinische Hochschule Hannover
- Joachim Lotz🇩🇪Medizinische Hochschule Hannover
- Christian Trautwein
- Günter Tusch🇩🇪Medizinische Hochschule Hannover
- Hans Jürgen Schlitt🇩🇪Medizinische Hochschule Hannover
- G. Regel🇩🇪Medizinische Hochschule Hannover
Resumen
El texto original del estudio, en el idioma en que se publicó.
This study investigated the influence of an enteral diet supplemented with arginine, omega-3 fatty acids, and nucleotides (Impact, Sandoz Nutrition, Berne, Switzerland) on the incidence of systemic inflammatory response syndrome (SIRS) and multiple organ failure (MOF) in patients after severe trauma. Thirty-two patients with an injury-severity score > 20 were included in this prospective, randomized, double-blind, controlled study. Primary endpoints were the incidence of SIRS and MOF. Secondary endpoints were parameters of acute phase and immune response as well as infection rate, mortality, and hospital stay. For statistical analysis 29 patients (test group n = 16, control n = 13) were eligible. In the test group, significantly fewer SIRS days per patient were found during 28 d. The difference was highly significant between d 8-14 (P < 0.001). MOF score was significantly lower in the test group on d 3 and d 8-11 (P < 0.05). Acute phase parameters showed lower C-reactive protein serum levels (significant on D day 4) and fibrinogen plasma levels (significant on d 12 and 14; P < 0.05). HLA-DR expression on monocytes showed significantly higher fluorescence activity on d 7. No significant difference was found for T-lymphocyte CD4/CD8 ratio, interleukin-2 receptor expression, infection rate, mortality (2/16 vs. 4/13), and hospital stay. The results of the study provide further support for beneficial effects of arginine, omega-3-fatty acids and nucleotide-supplemented enteral diet in critically ill patients.
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