Effect of dietary intake of omega-3 and omega-6 fatty acids on severity of asthma in children
Hodge L, Salome CM, Hughes JM, Liu-Brennan D, Rimmer J, Allman M, Pang D, Armour C, Woolcock AJ
The European respiratory journal · 124 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fisheries Research and Development Corporation
Según 1 financiador declarado.
Publicación
- Publicado
- 1998-02-01 · Eur Respir J · vol. 11 · número 2 · págs. 361–365
- Editorial
- European Respiratory Society
- Citado
- 193 citas · más que el 98% de estudios similares · 9.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 22 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Asthma and respiratory diseases · Edible Oils Quality and Analysis
- Palabras clave
- childhood asthma, omega-3 fatty acids, omega-6 fatty acids, fish oil supplementation, dietary fatty acid composition, plasma phospholipid fatty acids, TNF-α, eosinophils, lung function, asthma severity, canola oil, safflower oil
- MeSH
- lung, eosinophils, monocytes, humans, asthma, dietary fats, fatty acids, omega-3, fatty acids, unsaturated, fatty acids, omega-6, tumor necrosis factor-alpha, forced expiratory volume, blood cell count, child
9 autores
- Linda Hodge🇦🇺The University of Sydney; Royal Prince Alfred Hospital; Woolcock Institute of Medical Research
- CM Salome
- JM Hughes
- Damien Liu-Brennan🇦🇺The University of Sydney; Royal Prince Alfred Hospital; Woolcock Institute of Medical Research
- Janet Rimmer
- Margaret A Allman-Farinelli
- Dona Pang🇦🇺The University of Sydney; Royal Prince Alfred Hospital; Woolcock Institute of Medical Research
- Carol Lyn Armour
- A J Woolcock
Resumen
El texto original del estudio, en el idioma en que se publicó.
We assessed the clinical and biochemical effects in asthmatic children of fish oil supplementation and a diet that increases omega-3 and reduces omega-6 fatty acids. Thirty nine asthmatic children aged 8-12 yrs participated in a double-blind, randomized, controlled trial for 6 months during which they received fish oil capsules plus canola oil and margarine (omega-3 group) or safflower oil capsules plus sunflower oil and margarine (omega-6 group). Plasma fatty acids, stimulated tumour necrosis factor alpha (TNFalpha) production, circulating eosinophil numbers and lung function were measured at baseline and after 3 and 6 months of dietary modification. Day and night symptoms, peak flow rates and medication use were recorded for 1 week prior to laboratory visits. Plasma phospholipid omega-3 fatty acids were significantly greater in the omega-3 group at 3 and 6 months compared to the omega-6 group (p<0.001). In the omega-3 group TNFalpha production fell significantly compared with baseline (p=0.026), but the magnitude of change between groups did not reach significance (p=0.075). There were no significant changes in clinical outcome measures. Dietary enrichment of omega-3 fatty acids over 6 months increased plasma levels of these fatty acids, reduced stimulated tumour necrosis factor alpha production, but had no effect on the clinical severity of asthma in these children.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.